Comparison 1. Nedocromil Sodium vs Cromolyn Sodium.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Maximum percent decrease in FEV‐1	7	194	Mean Difference (IV, Random, 95% CI)	‐0.88 [‐4.49, 2.74]
1.1 children	5	138	Mean Difference (IV, Random, 95% CI)	‐0.18 [‐4.38, 4.01]
1.2 adults/combined	2	56	Mean Difference (IV, Random, 95% CI)	‐2.96 [‐13.21, 7.29]
2 Failure to achieve Complete Protection: Maximum % fall >10%	6	156	Odds Ratio (M‐H, Random, 95% CI)	0.95 [0.50, 1.81]
2.1 Children	4	100	Odds Ratio (M‐H, Random, 95% CI)	0.85 [0.39, 1.88]
2.2 Adults/combination	2	56	Odds Ratio (M‐H, Random, 95% CI)	1.17 [0.38, 3.63]
3 Failure to achieve Complete Protection: Maximum % fall >15%	6	170	Odds Ratio (M‐H, Random, 95% CI)	0.69 [0.33, 1.47]
3.1 Children	5	138	Odds Ratio (M‐H, Random, 95% CI)	0.89 [0.44, 1.81]
3.2 Adults/combination	1	32	Odds Ratio (M‐H, Random, 95% CI)	0.2 [0.04, 0.91]
4 Failure to achieve Clinical Protection: <50% improvement over placebo	6	156	Odds Ratio (M‐H, Random, 95% CI)	0.71 [0.36, 1.39]
4.1 Children	4	100	Odds Ratio (M‐H, Random, 95% CI)	0.76 [0.32, 1.79]
4.2 Adults/combination	2	56	Odds Ratio (M‐H, Random, 95% CI)	0.65 [0.22, 1.88]
5 Side Effects	3		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 unpleasant taste	3	94	Odds Ratio (M‐H, Random, 95% CI)	6.85 [0.77, 60.73]
5.2 sore throat	2	56	Odds Ratio (M‐H, Random, 95% CI)	3.46 [0.32, 37.47]