Comparison 3. Timing of Exercise ‐ post inhalation.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Maximum percent decrease in FEV‐1	7		Mean Difference (IV, Fixed, 95% CI)	Subtotals only
1.1 exercise <= 30 min.	7	194	Mean Difference (IV, Fixed, 95% CI)	‐0.88 [‐4.49, 2.74]
1.2 exercise 120 ‐ 140 min.	2	50	Mean Difference (IV, Fixed, 95% CI)	5.00 [‐3.01, 13.01]
1.3 exercise 240 min.	1	24	Mean Difference (IV, Fixed, 95% CI)	1.20 [‐10.42, 12.82]
2 Failure to achieve Complete Protection: Maximum % fall >10%	6		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 exercise <= 30 min.	6	156	Odds Ratio (M‐H, Random, 95% CI)	0.95 [0.50, 1.81]
2.2 exercise 120 ‐ 140 min.	2	50	Odds Ratio (M‐H, Random, 95% CI)	1.78 [0.52, 6.09]
2.3 exercise 240 min.	1	24	Odds Ratio (M‐H, Random, 95% CI)	1.67 [0.22, 12.35]
3 Failure to achieve Complete Protection: Maximum % fall >15%	6		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
3.1 exercise <= 30 min.	6	170	Odds Ratio (M‐H, Random, 95% CI)	0.72 [0.35, 1.48]
3.2 exercise 120 ‐ 140 min.	1	26	Odds Ratio (M‐H, Random, 95% CI)	1.87 [0.39, 8.89]
3.3 exercise 240 min.	0	0	Odds Ratio (M‐H, Random, 95% CI)	0.0 [0.0, 0.0]
4 Failure to achieve Clinical Protection: <50% improvement over placebo	6		Odds Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 exercise <= 30 min.	6	156	Odds Ratio (M‐H, Random, 95% CI)	0.71 [0.36, 1.39]
4.2 exercise 120 ‐ 140 min.	2	50	Odds Ratio (M‐H, Random, 95% CI)	3.30 [0.83, 13.11]
4.3 exercise 240 min.	1	24	Odds Ratio (M‐H, Random, 95% CI)	2.5 [0.36, 17.32]