Table 1.

Demographic and clinical data of subjects with delayed cutaneous reaction to ChAdOx1 nCoV‐19 vaccine^*

Patient	Patient 1	Patient 2	Patient 3	Patient 4
Age, years	44	30	58	53
Sex	Female	Female	Female	Female
Past medical history	Allergic rhinitis	No	Dyslipidemia	Vitiligo
Current medication	No	No	Atorvastatin	No
Past history of cutaneous reaction to vaccination	No	No	No	No
Day of skin reaction onset after COVID‐19 vaccination	4	5	17	14
Symptoms and signs of cutaneous reaction	Erythema, swelling, pain, tenderness	Erythema, swelling, pain, tenderness, pruritus	Erythema, swelling, pain, tenderness	Erythema, swelling, pruritus
Lesion size, cm	10 × 10	15 × 8	9 × 7.5	18 × 10
Immediate injection site reaction after vaccination	No	No	No	No
Immediate systemic symptoms after vaccination	Fever (38.5°C), chill, myalgia	Fever (38.4°C), chill, fatigue, headache	Fever (38.1°C), chill, fatigue, headache, myalgia	Fatigue, myalgia
Concurrent systemic symptoms with delayed skin reaction	No	No	No	No
Treatment	Oral predinisolone 30 mg for 4 days	Oral antihistamine, topical corticosteroid for 3 days	Oral antihistamine, topical corticosteroid for 4 days	Oral antihistamine, topical corticosteroid for 4 days
Duration of skin reaction, days	4	17	7	6
Treatment response	Complete resolution	Complete resolution	Complete resolution	Complete resolution

^*None of the patients had known previous SARS‐CoV‐2 infection. The clinical data were reported by patients, and symptoms were evaluated by a dermatologist or allergist.