Comparison 3. FP versus BDP or BUD, parallel group studies: dose ratio 1:2 subgroup by drug.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 FEV1	17	3640	Litres (Fixed, 95% CI)	0.04 [0.00, 0.07]
1.1 BDP	11	1943	Litres (Fixed, 95% CI)	0.02 [‐0.02, 0.06]
1.2 BUD	6	1697	Litres (Fixed, 95% CI)	0.09 [0.02, 0.15]
2 Change in FEV1 compared to baseline	12	2635	L/min (Fixed, 95% CI)	0.01 [‐0.02, 0.05]
2.1 BDP	7	1490	L/min (Fixed, 95% CI)	0.04 [‐0.01, 0.08]
2.2 BUD	5	1145	L/min (Fixed, 95% CI)	‐0.00 [‐0.05, 0.04]
3 FEV1 predicted	7	1444	% (Fixed, 95% CI)	0.42 [‐1.02, 1.86]
3.1 BDP	6	1189	% (Fixed, 95% CI)	0.63 [‐0.91, 2.16]
3.2 BUD	1	255	% (Fixed, 95% CI)	‐1.0 [‐5.06, 3.06]
4 Change in predicted FEV1	6	1306	% (Fixed, 95% CI)	‐0.39 [‐1.65, 0.86]
4.1 BDP	4	992	% (Fixed, 95% CI)	‐0.18 [‐1.63, 1.28]
4.2 BUD	2	314	% (Fixed, 95% CI)	‐1.04 [‐3.54, 1.47]
5 FVC	9	1854	Litres (Fixed, 95% CI)	0.05 [0.00, 0.10]
5.1 BDP	5	871	Litres (Fixed, 95% CI)	0.02 [‐0.04, 0.08]
5.2 BUD	4	983	Litres (Fixed, 95% CI)	0.12 [0.03, 0.20]
6 FVC % predicted	2	391	% (Fixed, 95% CI)	1.28 [‐0.84, 3.40]
6.1 BDP	2	391	% (Fixed, 95% CI)	1.28 [‐0.84, 3.40]
6.2 BUD	0	0	% (Fixed, 95% CI)	0.0 [0.0, 0.0]
7 Mean morning PEF	12	2955	L/min (Fixed, 95% CI)	5.89 [0.96, 10.82]
7.1 BDP	5	944	L/min (Fixed, 95% CI)	0.37 [‐6.07, 6.82]
7.2 BUD	7	2011	L/min (Fixed, 95% CI)	13.66 [6.01, 21.32]
8 Mean change in am PEF	17	4144	L/min (Fixed, 95% CI)	7.79 [5.28, 10.29]
8.1 BDP	6	1395	L/min (Fixed, 95% CI)	7.47 [2.99, 11.96]
8.2 BUD	10	2629	L/min (Fixed, 95% CI)	7.74 [4.65, 10.83]
8.3 Either	1	120	L/min (Fixed, 95% CI)	12.14 [‐2.23, 26.51]
9 Evening PEF	10	2656	L/min (Fixed, 95% CI)	1.53 [‐3.78, 6.84]
9.1 BDP	5	943	L/min (Fixed, 95% CI)	‐2.00 [‐8.30, 4.29]
9.2 BUD	5	1713	L/min (Fixed, 95% CI)	10.17 [0.32, 20.02]
10 Mean change in evening PEFR compared to baseline	10	2186	L/min (Fixed, 95% CI)	2.59 [‐0.36, 5.55]
10.1 BDP	6	1415	L/min (Fixed, 95% CI)	2.82 [‐0.96, 6.60]
10.2 BUD	4	771	L/min (Fixed, 95% CI)	2.24 [‐2.49, 6.97]
11 Clinic PEF	12	2545	L/min (Random, 95% CI)	17.04 [‐0.99, 35.07]
11.1 BDP	7	1276	L/min (Random, 95% CI)	22.68 [‐10.02, 55.39]
11.2 BUD	5	1269	L/min (Random, 95% CI)	13.08 [2.21, 23.95]
12 Change in Clinic PEF	6	1322	L/min (Fixed, 95% CI)	5.10 [‐1.18, 11.38]
12.1 BDP	3	853	L/min (Fixed, 95% CI)	4.51 [‐3.11, 12.13]
12.2 BUD	3	469	L/min (Fixed, 95% CI)	6.36 [‐4.73, 17.44]
13 Clinic PEF % predicted	3	630	% (Fixed, 95% CI)	2.00 [‐0.18, 4.18]
13.1 BDP	3	630	% (Fixed, 95% CI)	2.00 [‐0.18, 4.18]
13.2 BUD	0	0	% (Fixed, 95% CI)	0.0 [0.0, 0.0]