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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Adv Ther (Weinh). 2021 Mar 18;4(8):2100034. doi: 10.1002/adtp.202100034

Figure 3.

Figure 3.

T cells activated by synAPCs in vitro demonstrate cytotoxic activity. (A) pMHC liposomes stimulate T cells through pMHC-TCR interactions. Activated T cells then exert cytotoxic effects on target cells. (B) Histograms of CD44 and CD69 expression on T cells stimulated with synAPCs or anti-CD3/anti-CD28 antibodies. (C) P14 CD8+ T cells activated with Db-GP33 synAPCs have higher IFNγ expression when incubated with target cells pulsed with GP33 peptide than when incubated with control cells. Data shown as mean ± s.d. n=3 ****p<0.0001 by two-way ANOVA with Tukey’s multiple comparison test. (D) OT1 CD8+ T cells stimulated with Kb-OVA synAPCs show cytotoxic activity against B16-OVA target cells. Data shown as mean ± s.d. n=4 ***p<0.001, ****p<0.0001 by two-way ANOVA with Tukey’s multiple comparison test. Significance relative to untargeted controls at same E:T ratio.