Table 3.
Inflammatory, metabolic, and clinical data after 72‐h CytoSorb treatment, or parallel interval on ECMO alone
| Variable | VV‐ECMO + CytoSorb, n = 10 | ||
|---|---|---|---|
| Pre | Post | % change* | |
| Lactate dehydrogenase, U/L, median (IQR) | 856 (718–1115) | 425 (370–644) | −49 (−61 to −31) |
| Ferritin, ng/ml, median (IQR) | 2647 (1306–2815) | 1004 (576–2031) | −46 (−62 to −41) |
| d‐Dimer, ng/ml, median (IQR) | 5517 (2619–9363) | 4188 (2911–8810) | −7 (−22 to 0) |
| C‐reactive protein, mg/dL, median (IQR) | 117 (31–263) | 64 (7.8–105) | −55 (−75 to −47) |
| Procalcintonin, ng/ml, median (IQR) | 1.2 (0.21–3.8) | 0.19 (0.08–15) | −76 (−100 to −51) |
| Lactate, mmol/L, median (IQR) | 1.60 (1.32–2.55) | 1.35 (1.08–1.53) | −44 (−63 to −9.4) |
| IL‐2R, pg/ml, median (IQR) | 2143 (1147–15201) | 1279 (1097–2293) | −54 (−100 to −4.3) |
| IL‐6, pg/ml, median (IQR) | 22 (9–618) | 11 (7–146) | −86 (−100 to −31) |
| IL‐10, pg/ml, median (IQR) | 18 (9.5–73) | 5 (5–83) | −64 (−100 to −27) |
| Hemotocrit, %, median (IQR) | 33 (30–36) | 30 (27–32) | −9 (−14 to 8.3) |
| Absolute lymphocyte count, 1000/µl, median (IQR) | 5 (1.5–5) | 6 (4–11) | +140 (0 to 280) |
| Platelet count, 1000/µl, median (IQR) | 215 (138–262) | 94 (35–138) | −60 (−76 to −25) |
| Aspartate aminotransferase, U/L, median (IQR) | 39 (26–66) | 28 (21–79) | −10 (−43 to −2.6) |
| Alanine aminotransferase, U/L, median (IQR) | 41 (25–72) | 23 (20–56) | −40 (−42 to −10) |
| Creatinine, mg/dL, median (IQR) | 1.1 (0.8–2.3) | 1.4 (0.6–1.8) | −7 (−21 to 13) |
| pH, median (IQR) | 7.38 (7.28–7.42 | 7.42 (7.37–7.44) | 1 (0.3 to 1) |
| PCO2, mm Hg, median (IQR) | 42 (41–51) | 43 (41–44) | −1 (−13 to 10) |
| FiO2, %, median (IQR) | 40 (40–40) | 40 (40–45) | 0 (0 to 12.5) |
| PaO2/FiO2 (P:F ratio), median (IQR) | 185 (152–225) | 185 (170–260) | −9 (−34 to 6) |
| Vasopressin inotropic score, median (IQR) | 4.52 (0–12.25) | 1 (0–2.68) | −80 (−91 to −36) |
Abbreviations: FiO2, fraction of inspired oxygen; IL, interleukin; PCO2, partial pressure of carbon dioxide.
*
Grouped %change reported as per individual patient as (72 h – Pre)/Pre, mean of change p < .05.