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. Author manuscript; available in PMC: 2021 Sep 17.
Published in final edited form as: Neuroscientist. 2020 May 9;26(5-6):503–520. doi: 10.1177/1073858420916696

Figure 4:

Figure 4:

Multiple pathways in multiple disease models lead to tau mislocalization to dendritic spines. Models of AD, HD, PDD, FTDP-17 and LBD all implicate tau mislocalization to dendritic spines via phosphorylation or acetylation posttranslational modifications. The phosphorylation pattern of tau leading to mislocalization may be different in each condition.