Fig. 1.

Outcomes following treatment with different poly I:C preparations. C57BL/6J female adult mice were placed in an open field 2 h 50 min post-treatment and measures of locomotion (a) and rears (b) were accumulated over a 10 min trial period. Intraperitoneal treatments were saline (n = 5), 12 mg/kg Amersham poly I:C (n = 4) and 12 mg/kg Sigma poly I:C (n = 5). (c-e): Systemic expression of the pro-inflammatory cytokines IL-6 (c), TNFα (d) and IFNβ (e) were determined using ELISA in C57/BL6J female adult mice 3 h post-treatment in the same animals. All data are represented as mean +/- SEM and were compared using one-way ANOVA, followed by Bonferroni post-hoc tests. In a & b *p < 0.05 denotes significant differences from saline-treated animals while in c-e **p < 0.01 and ***p < 0.001 denote significant differences between the 2 poly I:C preparations. ND denotes not-detectable.