Fig. 7.

Selective effects of poly I:C on cognitive function in older animals. a) Animals were trained for 10 days × 10 trials per day (on the escape-from-water T-maze shown in b) and then tested at baseline (-24 h) before challenge with poly I:C at 12 mg/kg i.p. or sterile saline and testing for 3 blocks of 5 trials between 2-4 h, 4–6 h, 6–8 h and 24 h. Data are presented as mean ± SEM (Saline 6 m, n = 22, saline 24 m, n = 15, poly I:C 6 m, n = 22, poly I:C n, = 13). Data were analysed by 3 way ANOVA and * denotes an interaction of age and poly I:C.