Table 3.
Treatment of pregnant dams with different poly I:C preparations.
| Treatment & supplier | Lot No. | pI:C Dose, mg/kg | No. treated | ΔWt (dam) @ 24 h | Avg No.of offspring | Avg. Wt (g) offspring @ 10 m: F | Avg. Wt (g) offspring @ 10 m: M |
|---|---|---|---|---|---|---|---|
| Saline | 0 | 11 | + 3.3% | 6.6 | 25.6 | 34.6 | |
| poly I:C Amersham | 27–4732-01 | 20 | 1 | Died | 0 | – | – |
| 12 | 4 | −11.9% | 0 | – | – | ||
| 8 | 5 | −12.4% | 0 | – | – | ||
| 6 | 4 | −9.4% | 0 | – | – | ||
| 4 | 2 | −13.6% | 0 | – | – | ||
| 2 | 1 | −7.5% | 0 | – | – | ||
| poly I:C Sigma | 081M4054V | 20 | 5 | +1.2% | 7 | 26.8 | 34 |
| 12 | 3 | +4.4% | 5.7 | 25.3 | 32.6 | ||
| poly I:C Sigma | 122M4002V | 20 | 3 | +0.5% | 3.7 | 24.5* | 32.4 |
| 40 | 2 | −6.5% | 6 | 24.1** | 29.8 |
Avg: average; Wt: weight; Δ: change in; m: months; g: grams; M: male; F: female; * only 1 litter survived; ** weight at 3 months.