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. 2021 Sep 16;21:361. doi: 10.1186/s12883-021-02388-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Comparison of gray matter volume between CSVD patients and control participants. The numbers represents the z-axis coordinates of the corresponding plane. Red to yellow represents regions of the brain that have more significant gray matter atrophy in CSVD patients than controls at a threshold of p < 0.0001,after adjusting for age, sex and AHI. These brain regions include the bilateral cerebellum, right superior frontal gyrus, right inferior frontal gyrus, right thalamus, right temporal pole, right superior temporal gyrus, right lingual gyrus, right medial cingulate cortex and left anterior cingulate cortex