Table 2.
Results of binary logistic regression analyses between HRV parameters and CSVD
| Model 1a | Model 2b | |||
|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |
| Average heart rate during the sleep period, times/min | 1.047 (0.975 to 1.124) | 0.207 | 1.023(0.945 to 1.107) | 0.577 |
| HRV during awake period | ||||
| SDNN | 0.994(0.970 to 1.108) | 0.624 | 0.986(0.959 to 1.013) | 0.307 |
| RMSSD | 1.002(0.980 to 1.025) | 0.857 | 0.995(0.972 to 1.019) | 0.693 |
| PNN50 | 0.981(0.918 to 1.049) | 0.581 | 0.975(0.911 to 1.043) | 0.462 |
| LF/HF | 2.776(1.093 to 7.055) | 0.032* | 2.053(0.721 to 5.845) | 0.178 |
| HRV during sleep period | ||||
| SDNN | 0.970(0.938 to 1.002) | 0.069 | 0.943(0.903 to 0.985) | 0.009* |
| RMSSD | 1.003(0.982 to 1.026) | 0.758 | 0.997(0.974 to 1.020) | 0.778 |
| PNN50 | 0.982(0.922 to 1.045) | 0.558 | 0.975 (0.915 to 1.039) | 0.430 |
| LF/HF | 5.853(1.626 to 21.063) | 0.007* | 4.372(1.033 to 18.508) | 0.045* |
Statistical significance is reported as * (P < 0.05)
Abbreviations: HRV heart rate variability, CSVD cerebral small vessel disease, BMI body mass index, AHI apnea- hypopnea index, SDNN the standard deviation of normal-to-normal intervals, RMSSD the root mean square of successive differences in RR intervals, PNN50 the percentage of normal R-R intervals that differ by 50 ms, LF low-frequency power, HF high-frequency power
aModel 1: adjusted by sex, hypertension, previous stroke, hyperlipidemia, BMI
bModel 2: Model 1+ AHI, ODI, AHI × ODI (the interaction item of AHI and ODI)