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. 2021 Sep 16;18:42. doi: 10.1186/s12987-021-00274-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — A Waveform and hierarchies of pressures in the cerebral vasculature at baseline ICP. Systemic arterial pressure (P_A) with systolic peaks around 120 mmHg is followed by cerebral arteriolar pressure (P_ARL) which is somewhat lower. Pressures in the capillary bed (P_C) and veins (P_V) is markedly lower and displays a flattened waveform typical of capillary and venous circulation. Pressure in the sagittal sinus (P_SSS) is the lowest in the intracranial space and is typically lower than ICP. B Waveform and hierarchies of pressures in the ventricles (ICP_VEN), brain (ICP_BR), and subarachnoid space (ICP_SAS). At baseline, ventricular pressure is slightly higher than brain intraparenchymal pressure preventing ventricular collapse. Subarachnoid pressure (ICP_SAS) is slightly lower than both ventricular and brain intraparenchymal pressure, allowing flow of both ventricular CSF and cerebral interstitial fluid into the subarachnoid space