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. 2021 Sep 16;18:42. doi: 10.1186/s12987-021-00274-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — A Pressure–volume curve obtained by simulating injection of fluid of increasing volume into the intracranial space demonstrating the expected exponential-like rise in ICP with higher volumes. B ICP waveforms with increasing ICP. As brain parenchymal ICP (ICP_BR) rises from 10 to 50 mmHg, the model demonstrates the typical increase in ICP pulse pressure that results from decreased intracranial compliance