Fig. 5.

Changes in ICP with changes in resistances in the model. A Increased resistance to CSF outflow (R_OUT) that occurs with non-absorptive hydrocephalus leads to the expected rise in brain intraparenchymal pressure (ICP_BR). B Increased resistance to CSF flow in the ventricular system (R_VEN) which is typically seen in obstructive hydrocephalus also leads to a sharp rise in ICP_BR. C A rise in resistance to the bulk flow of cerebral interstitial fluid (R_BF) leads to a pronounced rise in ICP_BR which is characteristic of cerebral edema. D Similarly, a disruption of the blood–brain barrier (R_BBB) leads to a marked rise in ICP_BR as the R_BBB decreases and allows more fluid to cross from the cerebrovascular compartment into the brain