. 2021 Sep 16;18:42. doi: 10.1186/s12987-021-00274-z

Table 2.

Changes in model output parameters as ICP rises from baseline to 30 mmHg under four conditions

	R_OUT	R_VEN	R_BF	R_BBB
Total brain volume ( $ml$ )	+ 16	− 62	+ 94	+ 94
Ventricular volume ( $ml$ )	+ 20	+ 133	− 25	− 25
Subarachnoid space volume ( $ml$ )	+ 10	− 25	− 24	− 24
Cerebral blood volume ( $ml$ )	− 41	− 41	− 40	− 40
CBF ( ${m l 100 g r}^{- 1}$ $\min^{- 1}$ )	− 26	− 26	− 26	− 26

The Table describes the output parameters under four input conditions: increased resistance to CSF absorption, increased resistance to ventricular CSF flow, increased resistance to bulk flow of ISF, and breakdown of the BBB. R_OUT: resistance to cerebrospinal fluid (CSF) outflow; R_VEN: resistance to CSF flow in the ventricular system; R_BF: resistance to bulk flow of cerebral interstitial fluid; R_BBB: resistance to flow of fluid across the blood–brain barrier; CBF: cerebral blood flow