Table 1.
Characteristics of 128 healthy pregnant Caucasian women, 120 blood donors and their plasma Fibulin-1 concentrations
| Women | Samples | Fibulin-1, μg/mL | ||||
|---|---|---|---|---|---|---|
| n | % | n | % | mean | SD | |
| Non-pregnant reference groupa | 62F/58M | 120 | 15.7 | 4.5 | ||
| Pregnant women overall | 128 | 632 | 27.4 | 13.2 | ||
| Age (years) | 128 | 632 | ||||
| 20-29 | 44 | 35 | 198 | 31 | 25.6 | 12.9 |
| 30-39 | 81 | 63 | 418 | 66 | 28.2 | 13.3 |
| ≥40 | 3 | 2 | 16 | 3 | 28.7 | 12.2 |
| Parity | 128 | 632 | ||||
| 0 | 51 | 40 | 255 | 40 | 25.1 | 12.8 |
| 1 | 59 | 46 | 289 | 46 | 28.2 | 13.4 |
| 2+ | 18 | 14 | 88 | 14 | 31.3 | 12.7 |
| Body mass index (kg/m2) | 127 | 628 | ||||
| Underweight <18.5 | 5 | 4 | 22 | 4 | 18.7 | 10.0 |
| Normal weight 18.5-24.9 | 98 | 77 | 491 | 78 | 27.8 | 13.1 |
| Overweight 25.0-29.9 | 22 | 17 | 107 | 17 | 27.9 | 13.9 |
| Obese 30.0-34.9 | 2 | 2 | 8 | 1 | 22.5 | 9.0 |
| Smoking habits | 128 | 632 | ||||
| Non-smoker | 107 | 84 | 531 | 84 | 28.2 | 13.7 |
| Smoker | 21 | 16 | 101 | 16 | 23.2 | 9.3 |
| Mode of conception | 128 | 632 | ||||
| Spontaneous | 126 | 98 | 625 | 98 | 27.5 | 13.2 |
| In-vitro fertilization | 1 | 1 | 3 | 1 | 16.3 | 1.1 |
| Insemination | 1 | 1 | 4 | 1 | 14.3 | 1.3 |
| Gestational weeks | - | 632 | ||||
| 12-20 | 66 | - | 93 | 15 | 23.4 | 12.2 |
| 21-28 | 90 | - | 121 | 19 | 26.4 | 11.4 |
| 29-34 | 59 | - | 60 | 10 | 32.8 | 14.7 |
| 35-42 | 50 | - | 63 | 10 | 36.0 | 14.3 |
| Delivery | 98 | - | 98 | 15 | 30.4 | 14.6 |
| 1st day after delivery | 101 | - | 101 | 16 | 25.2 | 10.9 |
| 2nd day after delivery | 96 | - | 96 | 15 | 22.7 | 10.8 |
| Pre-eclampsia | 128 | 632 | ||||
| Not present | 116 | 91 | 571 | 90 | 27.3 | 13.2 |
| Present | 12 | 9 | 61 | 10 | 29.1 | 13.1 |
| PPROM | 128 | 632 | ||||
| Not present | 119 | 93 | 603 | 95 | 28.0 | 13.1 |
| Present | 9 | 7 | 29 | 5 | 15.4 | 6.0 |
| Mode of delivery | 128 | 632 | ||||
| Vaginal birth | 88 | 69 | 396 | 63 | 28.5 | 13.1 |
| Elective cesarean section | 24 | 19 | 147 | 23 | 27.4 | 13.8 |
| Emergency cesarean section | 16 | 12 | 89 | 14 | 23.2 | 12.0 |
| Postpartum haemmorhageb | 128 | 632 | ||||
| Not present | 120 | 94 | 580 | 92 | 27.7 | 13.4 |
| Present | 8 | 6 | 52 | 8 | 23.4 | 9.4 |
| Birth weight (grams) | 126 | 621 | ||||
| <2500 | 6 | 5 | 20 | 3 | 23.6 | 14.3 |
| 2500-2999 | 18 | 14 | 84 | 13 | 24.6 | 11.3 |
| 3000-3499 | 42 | 33 | 215 | 35 | 27.3 | 13.4 |
| 3500-3999 | 43 | 34 | 224 | 36 | 29.7 | 14.1 |
| 3999> | 17 | 14 | 78 | 13 | 25.1 | 10.8 |
Fibulin-1 concentrations in different socio-demographic and clinical subgroups of the total study population. The data are presented as counts, percentages (%), or means and standard deviations (SD). aNon-pregnant reference group consist of 62 female (F) and 58 male (M) blood donors. b Defined as >500 mL during vaginal delivery and >1000 mL during cesarean section