Table 3.
Sensitivity for meta-analysis based on QLQ-C30
| Including Adamowicz et.al.:data pre-treatment | Including Adamowicz et.al.: data post-treatment | Excluding data from Adamowicz et.al. | |
|---|---|---|---|
| Overall HRQoL | |||
| Mean (CI) | 62.01 (57.72–66.29) | 62.89 (56.78–69.00) | 59.31 (55.62–63.00) |
| Heterogeneity: Q | 7.47, p = 0.02 | 17.77, p = 0.00 | 0.08, p = 0.78 |
| Heterogeneity: I2 | 69.60% | 85.24% | 0.00% |
| Symptoms | |||
| Appetite loss | |||
| Mean (CI) | 23.61 (9.72–37.51) | 23.70 (9.98–37.42) | 30.27 (21.08–39.46) |
| Heterogeneity: Q | 45.47, p = 0.00 | 45.95, p = 0.00 | 2.97, p = 0.08 |
| Heterogeneity: I2 | 94.67% | 94.70% | 66.29% |
| Constipation | |||
| Mean (CI) | 20.77 (15.49–26.05) | 20.57 (14.79–26.36) | 23.67 (19.15–28.18) |
| Heterogeneity: Q | 8.43, p = 0.01 | 10.33, p = 0.01 | 0.80, p = 0.37 |
| Heterogeneity: I2 | 73.89% | 78.04% | 0.00% |
| Diarrhea | |||
| Mean (CI) | 16.20 (5.86–26.54) | 19.09 (14.39–23-79) | 21.57 (16.41–26.73) |
| Heterogeneity: Q | 47.50, p 0 0.00 | 7.02, p = 0.03 | 1.49, p = 0.22 |
| Heterogeneity: I2 | 94.23% | 69.78% | 33.00% |
| Dyspnea | |||
| Mean (CI) | 17.97 (5.45–30.49) | 18.23 (6.09–30.37) | 22.64 (6.97–38.31) |
| Heterogeneity: Q | 41.63, p = 0.00 | 38.42, p = 0.00 | 15.25, p = 0.00 |
| Heterogeneity: I2 | 96.33% | 96.15% | 93.44% |
| Fatigue | |||
| Mean (CI) | 34.64 (19.96–49.33) | 36.25 (24.57–47.92) | 41.93 (33.65–50.21) |
| Heterogeneity: Q | 80.88, p = 0.00 | 49.73, p = 0.00 | 3.40, p = 0.07 |
| Heterogeneity: I2 | 96.65% | 94.78% | 70.62% |
| Financial impact | |||
| Mean (CI) | 30.81 (10.25–51.37) | 31.15 (10.35–51.95) | 27.22 (−6.34–60.77) |
| Heterogeneity: Q | 115.79, p = 0.00 | 122.74, p = 0.00 | 64.98, p = 0.00 |
| Heterogeneity: I2 | 98.39% | 98.44% | 98.46% |
| Nausea/vomiting | |||
| Mean (CI) | 15.51 (−0.39–31.41) | 15.99 (0.73–31.25) | 20.87 (−1.07–42.82) |
| Heterogeneity: Q | 41.26, p = 0.00 | 35.49, p = 0.00 | 22.28, p = 0.00 |
| Heterogeneity: I2 | 98.10% | 97.99% | 95.51% |
| Pain | |||
| Mean (CI) | 24.59 (19.89–29.29) | 22.82 (14.39–31.24) | 27.42 (23.52–31.31) |
| Heterogeneity: Q | 8.15, p = 0.02 | 32.50, p = 0.00 | 0.06, p = 0.81 |
| Heterogeneity: I2 | 71.76% | 91.66% | 0.00% |
| Sleep disturbance | |||
| Mean (CI) | 33.27 (28.77–37.76) | 32.93 (30.07–35.78) | 30.25 (25.21–35.28) |
| Heterogeneity: Q | 4.28, p = 0.12 | 1.94, p = 0.38 | 0.18, p = 0.67 |
| Heterogeneity: I2 | 53.09% | 17.20% | 0.00% |
Q: Cochran’s Q. I2 = 100% x (Q-dt)/Q, where df is the degrees of freedom and Q the Cochran’s heterogeneity statistics