Table 2.
Enrollment lipids and lipoproteins, endothelial, and inflammatory biomarkers by outcome
| Variable | N | All patients | Rapid recovery | CCI | Early death | p Value*,^ |
|---|---|---|---|---|---|---|
| Lipid measures | ||||||
|
Total cholesterol (mg/dL) |
171 | 91 (67, 117) | 100 (76, 120) | 67 (56, 98) | 71 (58, 117) | < 0.001 |
| HDL-C (mg/dL) | 171 | 19 (8, 30) | 22 (10, 32) | 14.5 (6, 20) | 8 (5, 26) | 0.001 |
| LDL-C (mg/dL) | 164 | 43.5 (27, 64) | 50 (35, 67) | 31 (21, 47) | 25 (17, 59) | < 0.001 |
| Triglycerides (mg/dL) | 171 | 121 (78, 150) | 120 (84, 149) | 125 (75, 159) | 118 (73, 143) | 0.657 |
| HDL inflammatory index | 169 | 1.9 (1.2, 3.34) | 1.7 (1.2, 3.56) | 1.9 (1.3, 3.2) | 2.6 (1.67, 3.1) | 0.556 |
|
PON-1 activity (nmol/min/ml) |
170 | 54 (29, 107) | 66 (37, 115) | 37 (25, 66) | 43 (13, 83) | 0.003 |
| ApoA-1 (ng/mL) | 152 | 1,100,000 (741,249, 1,500,000) | 1,300,000 (919,877, 1,600,000) | 819,148 (635,390, 1,000,000) | 722,862 (564,171.5, 1,090,858.5) | < 0.001 |
| Endothelial markers | ||||||
| E-selectin (ng/mL) | 133 | 68 (47, 143) | 83 (51, 160) | 55 (33, 78) | 69 (52, 227) | 0.025 |
| ICAM (ng/mL) | 139 | 426 (306, 617) | 390 (291, 558) | 448 (324, 669) | 495 (439, 805) | 0.055 |
| Inflammatory markers | ||||||
| MPO (µg/L) | 150 | 203 (139, 334) | 1889 (130, 323) | 245 (161, 405) | 277 (175, 459) | 0.078 |
| GRO (pg/mL) | 152 | 1081 (537, 2000) | 1100 (555, 1787) | 1164 (533, 3519) | 561 (324, 1189) | 0.291 |
| G-CSF (pg/mL) | 164 | 334 (151, 1168) | 329 (150, 1111) | 335 (142, 799) | 919 (181, 587) | 0.256 |
| GM-CSF (pg/mL) | 164 | 12 (4, 41) | 10 (4, 39) | 13 (4, 42) | 16 (7, 60) | 0.244 |
| IFNy (pg/mL) | 164 | 28 (8, 62) | 29 (8, 62) | 25 (8, 53) | 27 (11, 75) | 0.815 |
| IL-10 (pg/mL) | 164 | 74 (31, 179) | 64 (29, 161) | 77 (52, 163) | 291 (37, 1040) | 0.082 |
| IL-8 (pg/mL) | 164 | 67 (31, 1501) | 44 (23, 1034) | 108 (57, 212) | 180 (142, 812) | < 0.001 |
| IL-6 (pg/mL) | 164 | 176 (64, 520) | 152 (52, 361) | 259 (71, 919) | 312 (152, 1986) | 0.017 |
| Il-12p70 (pg/mL) | 164 | 12 (4, 27) | 11 (4, 26) | 12 (4, 22) | 13 (4, 55) | 0.726 |
| IP-10 (pg/mL) | 164 | 1066 (484, 2738) | 981 (441, 2623) | 900 (4878, 2192) | 2235 (1638, 3807) | 0.028 |
| MCP-1 (pg/mL) | 164 | 739 (460, 1732) | 669 (441, 1397) | 813 (523, 1779) | 1246 (701, 3450) | 0.071 |
| MIP-1a (pg/mL) | 164 | 8 (3, 18) | 8 (3, 20) | 6 (4, 12) | 16 (8, 31) | 0.055 |
| TNFα (pg/mL) | 164 | 70 (45, 138) | 70 (40, 137) | 63 (46, 118) | 116 (63, 200) | 0.103 |
Bold values are significant after Bonferroni correction for multiple comparisons
Data is median (1st quartile, 3rd quartile); *Wilcoxon rank-sum test; ^after Bonferroni adjustment for multiple tests, significant if < 0.002(0.05/47 tests). Comparisons are bivariate between rapid recovery vs. CCI or early death