Table 3.

The effect estimates, test of heterogeneity and test of pleiotropy of exposure on cholecystitis

	MR methodology	Effect estimates on cholecystitis				Test of heterogeneity		Test of pleiotropy	p value
		OR	Lower	Upper	p value	Cochrane Q test	p value	MR-Egger intercept
Total cholesterol	Inverse variance weighted (multiplicative random effects)	0.9994228	0.9994222	0.9994233	0.2960	135.009	0.053
	MR Egger	0.9987183	0.9987161	0.9987205	0.1893	133.856	0.053	0.0000406	0.335
	Inverse variance weighted (fixed effects)	0.9994228	0.9994223	0.9994232	0.2347	135.009	0.053
	Weighted median	0.9994726	0.9994719	0.9994733	0.5640
HDL-C	Inverse variance weighted (multiplicative random effects)	0.9997020	0.9997017	0.9997023	0.5650	188.737	0.000
	MR Egger	0.9988892	0.9988871	0.9988913	0.2510	187.188	0.000	0.0000446	0.319
	Inverse variance weighted (fixed effects)	0.9997020	0.9997018	0.9997023	0.4740	188.737	0.000
	Weighted median	0.9996111	0.9996106	0.9996117	0.5870
LDL-C	Inverse variance weighted (multiplicative random effects)	0.9984483	0.9984499	0.9984468	0.0080	116.489188	0.004851838
	MR Egger	0.9987160	0.9987180	0.9987140	0.1893	116.200524	0.004109598	− 0.000021	0.658974602
	Inverse variance weighted (fixed effects)	0.9984483	0.9984496	0.9984471	0.0008	116.489188	0.004851838
	Weighted median	0.9991214	0.9991225	0.9991203	0.3380
Triglycerides	Inverse variance weighted (multiplicative random effects)	0.9990893	0.9990882	0.9990903	0.2380	96.010	0.021
	MR Egger	0.9980924	0.9980889	0.9980958	0.1680	93.378	0.027	0.0000655	0.168
	Inverse variance weighted (fixed effects)	0.9990893	0.9990884	0.9990902	0.1360	96.010	0.021
	Weighted median	0.9983449	0.9983424	0.9983474	0.1360

TC total cholesterol, HDL-C HDL cholesterol, LDL-C LDL cholesterol, TG triglycerides, OR odds ratio, upper upper bounds of 95% confidence interval, lower lower bounds of 95% confidence interval. p value was adjusted by false discovery rate approach