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Effects of co-treatment or pretreatment of SKQ1 or MitoQ on Dox-induced increase in mitochondrial SO levels. Co-treatment (A) or pretreatment (B) of SKQ1 and MitoQ significantly attenuated Dox-induced mitochondrial SO levels. Pretreatment (C-D) showed better reduction in mitochondrial SO levels than co-treatment only at a higher dose (1–5 μM). Moreover, MitoQ exerted better reduction than SKQ1 at most doses. **p < 0.01 vs Dox; #p < 0.05, ##p < 0.01 vs MitoQ or SKQ1, respectively
