Table 1.
Clinical characteristics at diagnosis of the 6 R/R ALAL-NOS patients
| No | Sex | Age (y) | Diagnosis | WBC (109/L) | BM blast cell(%) | Chromosome | Fish | Gene mutation(NGS) |
|---|---|---|---|---|---|---|---|---|
| 1 | F | 66 | ALAL-NOS | 3.37 | 87.0 | 46,XX | Negative | RUNX1, FAT1, BCOR |
| 2 | M | 16 | ALAL-NOS | 25.18 | 91.50 | 46, XY, t(10; 12)(p11.2; q15), inc[4]/ 46, XY | Negative | PHF6, NRAS, RAD21, CALR |
| 3 | M | 23 | ALAL-NOS | 62.9 | 83.5 | 46,XY | Negative | PHF6 ; IKZF1 ; KMT2D ;WT1;PTPN11;EED |
| 4 | M | 29 | ALAL-NOS | 2.36 | 68.0 | 46,XY | MLL(+) | IL7R |
| 5 | F | 52 | ALAL-NOS | 5.57 | 73.5 |
46 XX,del(22)(q13)[3]/ 46,XX,del(8)(p21),del(22)(q13)[15]/ 46,XX,t(3;6),del(8)(p21),del(22)(q13)[1]/ 46,XX[1] |
Negative | BCOR |
| 6 | M | 22 | ALAL-NOS | 55.5 | 79.0 | 47,XY,del(5)(q31),del(13)(?q12q22),+mar[20] | Negative | NOTCH1 KMT2C PTPN11 TP53 |