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. 2021 Sep 16;10:46. doi: 10.1186/s40164-021-00239-w

Table 2.

Initial treatment, salvage therapy and outcome of 6 R/R ALAL-NOS patients

No. Previous treatment Reinduction treatment VEN dose, (mg) VEN days Response to VEN combination HSCT Outcome OS(m)
1 Chemotherapy and HSCT VEN + AZA 400 mg 28d CR N Dead 36
2 VDCP NR; DAC + HACVP NR VEN + AAVP 400 mg 14d CR Y CR 15
3 VDCP NR; DAC + HACVP NR VEN + AAVP PR; DAC + VEN + AAVP 400 mg 21d CR Y Dead 9
4 DAC + AAVP NR VEN + HOAP

200 mg

(with voriconazole)

14d CRi Y CR 8
5 VDCP + AA NR VEN + CA 400 mg 14d CR Y CR 7
6 AACVP NR VEN + HOAP 400 mg 14d CR Y CR 5

VEN, venetoclax; DAC, decitabine; AZA, azacitidine; VCR, vincristine; DNR, daunorubincin; CTX, cyclophosphamide; Pred, prednisone; HHT, homoharringtonine; Ara-c, cytarabine; Acla, aclarubicin. VDCP:VCR + DNR + CTX + Pred; HACVP, HHT + Ara-c + CTX + VCR + Pred; AAVP, Ac,a + Ara-c + VCR + Pred; AA, Acla + Ara-c; CA cladribine + LDAC; AACVP, Acla + Ara-c + CTX + VCR + Pred; HOAP: HHT + Ara-c + VCR + Pred; HSCT, hematopoietic stem cell transplantation