Table 2.
No. | Previous treatment | Reinduction treatment | VEN dose, (mg) | VEN days | Response to VEN combination | HSCT | Outcome | OS(m) |
---|---|---|---|---|---|---|---|---|
1 | Chemotherapy and HSCT | VEN + AZA | 400 mg | 28d | CR | N | Dead | 36 |
2 | VDCP NR; DAC + HACVP NR | VEN + AAVP | 400 mg | 14d | CR | Y | CR | 15 |
3 | VDCP NR; DAC + HACVP NR | VEN + AAVP PR; DAC + VEN + AAVP | 400 mg | 21d | CR | Y | Dead | 9 |
4 | DAC + AAVP NR | VEN + HOAP |
200 mg (with voriconazole) |
14d | CRi | Y | CR | 8 |
5 | VDCP + AA NR | VEN + CA | 400 mg | 14d | CR | Y | CR | 7 |
6 | AACVP NR | VEN + HOAP | 400 mg | 14d | CR | Y | CR | 5 |
VEN, venetoclax; DAC, decitabine; AZA, azacitidine; VCR, vincristine; DNR, daunorubincin; CTX, cyclophosphamide; Pred, prednisone; HHT, homoharringtonine; Ara-c, cytarabine; Acla, aclarubicin. VDCP:VCR + DNR + CTX + Pred; HACVP, HHT + Ara-c + CTX + VCR + Pred; AAVP, Ac,a + Ara-c + VCR + Pred; AA, Acla + Ara-c; CA cladribine + LDAC; AACVP, Acla + Ara-c + CTX + VCR + Pred; HOAP: HHT + Ara-c + VCR + Pred; HSCT, hematopoietic stem cell transplantation