Fig. 8.
UBE2S induces Olaparib resistance through Wnt/β-catenin in xenograft model. 6 weeks old mice were subcutaneously injected with A2780 cells. When the tumor volumes reached about 50–100 mm3, tumor-bearing mice then received intraperitoneal injection of Olaparib (20 mg/kg, once a day) or/and XAV-939 (15 mg/kg, once a day). Two weeks after injection, the mice were sacrificed to harbor tumor tissues which were photographed. A Tumors from each group were shown. B The tumor volumes of each group. C The body weight of each group. D Western blot was performed to detect the protein levels of PARP, cleaved caspase 3, UBE2S, and β-actin in tumor tissues. E Quantification of the protein levels in (D). (Data are mean ± SEM, #p > 0.05, *p < 0.05, **p < 0.01, n = 6)