Table 1.
The characteristics of dysregulated circRNAs in CRC
| CircRNA | GENE Related miRNA |
Expression | Targeted molecules/pathways | Function | References (DOI) | ||
|---|---|---|---|---|---|---|---|
| circ_0007142 | miR-455-5p | Up | SGK1 | Regulates cell proliferation, apoptosis, migration, and invasion | [48] | 2021 | |
| hsa_circ_102049 | miR-761, miR-192-3p | Up | FRAS1 | Promoting liver metastasis | [49] | 2021 | |
| LONP2 | Mir-17 | Up | DGCR8 | Prognostic predictor for anti-metastasis target | [50] | 2020 | |
| CircPTK2 (hsa_circ_0005273) | Up | binding to vimentin protein |
Metastasis and may serve as a potential therapeutic target for CRC metastasis, Promote EMT |
[51] | 2020 | ||
| circPACRGL |
miR142-39 506-3p |
Up | TGF-β1 | Promoted CRC cell proliferation, migration, and invasion, as well as differentiation | [52] | 2020 | |
| hsa_circ_0053277 | miR-2467-3p | Up | MMP14 | Facilitated the development of CRC accelerated cell proliferation | [37] | 2020 | |
| Hsa_circ_001680 | miR-340 | Up | BMI1 | Enhance the proliferation and migration capacity of CRC cells | [53] | 2020 | |
| circSAMRCC1 | miR-140-3p | Up | MMP-2, MMP-9, VEGF | Cell viability, migration, and invasion | [54] | 2020 | |
| CircHIPK3 | miR-1207-5p | Up | FMNL2 | Promote Cell Progression, migration, and invasion in CRC | [55] | 2020 | |
| circ-HIPK3 | Mir-7 | Up | FAK/IGF1R/EGFR/YY1 |
Promotes CRC growth and metastasis Prognostic |
[56] | 2020 | |
| circHUWE1 | miR-486 | Up | Promotes Cell Proliferation, Migration, and Invasion | [57] | 2020 | ||
| circVAPA | miR-101 | Up | CREB5 | Promotes CRC cell proliferation, migration, invasion, and inhibit apoptosis | [38] | 2020 | |
| CircAPLP2 | miR-101-3p | Up |
Notch Signaling Notch1 |
Promotes proliferation and metastasis | [58] | 2020 | |
| circ-FARSA | miR-330-5p | Up | LASP1 | Proliferation, migration, and invasion of CRC cells in vitro | [59] | 2020 | |
| CircAGFG1 | miR-4262 and miR-185-5p | Up |
WNT/β-catenin CTNNB1 |
Promote metastases | [60] | 2020 | |
| circ5615 | miR-149-5p | Up | WNT/β-catenin pathway | Exerted oncogenic function | [61] | 2020 | |
| circular RNA 001,971 | miR-29c-3p | Up | VEGFA |
CRC cell proliferation, Invasion and angiogenesis |
[62] | 2020 | |
| CircPRMT5 | miR-377 | Up | E2f3 | Cell proliferation and migration | [63] | 2020 | |
| CircularRNA NOX4 | microRNA-485-5p | Up | CKS1B | Promotes the development of colorectal cancer | [64] | 2020 | |
| circRAE1 | miR-338-3p | Up | TYRO3 | Promotes colorectal cancer cell migration and invasion | [65] | 2020 | |
| Hsa_circ_0079662 | Up |
TNF-α HOXA9 |
Induces the resistance mechanism of the chemotherapy drug oxaliplatin through the TNF‐α pathway | [66] | 2020 | ||
| Hsa_circ_0026416 | miR-346 | Up | NFIB | Promotes proliferation and migration | [39] | 2020 | |
| circ_0136666 | miR-383 | Up |
CREB1 proteins (HK2 and LDHA) |
Accumulation on the proliferation and glycolysis and the promoting impact on the apoptosis of CRC | [67] | 2020 | |
| hsa_circRNA_102209 | miR-761 | Up | Promotes the growth and metastasis | [68] | 2020 | ||
| Hsa_circ_0005963 | miR-122 | Up | PKM2 | Chemoresistance. In vitro and in vivo studies | [69] | 2020 | |
| Circ TUBB | Interacting with smoking can enhance colorectal cancer risk | [70] | 2020 | ||||
| CircRNA_101951 | Up | KIF3A | Promote migration and invasion | [71] | 2020 | ||
|
Circ-PNN hsa_circ_0101802) |
miR-6833 miR-1301-3P |
Up | [72] | 2020 | |||
|
circ-ABCC1 hsa_circ_0000677 |
Up | Wnt/β-catenin pathway | circ-ABCC1 was confirmed to facilitate CRC progression | [73] | 2020 | ||
| CircFNDC3B | miR-937-5p | Up | circFNDC3B-enriched exosomes can inhibit angiogenesis and CRC progression | [74] | 2020 | ||
| circ_0060745 | miR-473,6 | Up | CSE1L | Promotes Colorectal Cancer Cell Proliferation and Metastasis | [75] | 2020 | |
| circRUNX1 | miR-145-5p | Up | IGF1 signaling | Promote Cell Growth Metastasis/Proliferation/ migration | [76] | 2020 | |
| circHOMER1 | miR-138-5p | Up | HEY1 |
A decrease in glucose consumption Treated with lidocaine, indicating the inhibition of CRC cell viability mediated by lidocaine through suppressing aerobic glycolysis |
[77] | 2020 | |
| Hsa_circ_0001806 | miR-193a-5p | Up | COL1A1 | Correlated with TNM stage, depth of invasion, lymphatic metastasis, and distant metastasis | [78] | 2020 | |
| circMAT2B | miR-610 | Up | E2F1 | Induces Colorectal Cancer Proliferation | [79] | 2020 | |
| circ_0000512 | miR-296-5p/ | Up | RUNX1 | Cell Proliferation cell viability and colony formation | [80] | 2020 | |
| Circ_0056618 | miR-206 | Up | CXCR4 VEGF-A | Promoted cell proliferation, migration, and angiogenesis | [81] | 2020 | |
| CircRNA_0001946 | MicroRNA-135a-5p | Up | EMT | A tumor promoter by activating the miR-135a | [82] | 2020 | |
| Hsa_circ_0038646 | miR-331-3p | Up | GRIK3 | Promotes cell proliferation and migration | [83] | 2020 | |
| Circ_0007031 | miR-760 | Up | DCP1A | Regulate the Growth and Chemoradiotherapy Resistance might play a positive role | [84] | 2020 | |
| Circ-PRKDC | miR-375/ | Up | FOXM1 Axis and Wnt/β-Catenin | Circ-PRKDC enhanced 5-FU resistance in CRC | [85] | 2020 | |
| CircRNA UBAP2 | Mir-199a | Up | VEGFA | Facilitated CRC progression | [86] | 2020 | |
| Hsa_circ_0000231 | miR-502-5p | Up | MYO6 |
CRC progression It has a role in glycolysis |
[87] | 2020 | |
| circGLIS2 | miR-671 | Up | NF-κB | Promotes colorectal cancer cell motility | [88] | 2020 | |
| Circular RNA CCDC66 | Up | PI3KK | Apoptosis | [89] | 2020 | ||
| circCCDC66 | miR-3140 | Up | autophagy | Promotes the tumorigenesis | [90] | 2020 | |
| circ-CCDC66 | miR-33b/miR-93/ | Up |
DNMT3B/EZH2/ MYC/YAP1 |
Promotes CRC growth and metastasis | [91] | 2020 | |
| Hsa_circ_0128846 | hsa-miR-1184 | Up | YAP signaling | Promotes tumorigenesis | [92] | 2020 | |
| Hsa_circ_0007534 |
miR613 SLC25A22 |
Up | SLC25A22 | Promote proliferation was correlated with tumor stage and lymph node metastasis | [93] | 2020 | |
| CircFAT1 |
miR-520b miR-302c-3p |
Up | UHRF1 | CRC cell proliferation, apoptosis, and glycolysis | [94] | 2020 | |
| CircFADS2 | Up | Biomarkers of CRC | [95] | 2020 | |||
| Circ-000166 | miR-326 | Up | LASP1 | Cell growth and apoptosis in CRC cell lines | [96] | 2020 | |
| circ-ACAP2 | Mir21-5p | Up | Tiam1 | Promotes CRC cell proliferation, migration, and invasion | [49] | 2020 | |
| circ-ZNF609 | miR-150 | Up | Gli1 | Promotes CRC cell migration | [33] | 2020 | |
| circ-NSD2 | miR-199b | Up | 5p/DDR1/JAG1 | Promotes CRC metastasis | [97] | 2020 | |
| Circ-DENND4C | miR-760 | Up | SLC2A1 | Promote Migration and glycolysis | [98] | 2020 | |
| circ-Lgr4 | Up | circLgr4-peptide/Lgr4/Wnt/β-catenin | Promotes CRC stem cell self-renewal, tumorigenesis and invasion | [99] | 2020 | ||
| hsa_circ_000984 | miR-106b | Up | CDK6 | Promotes CRC growth and metastasis | [100] | 2020 | |
|
Has _circ -140,388 (circHUWE1) |
Mir486 .5p | Up |
PLAGL2 IGF2 WNT- β CATENIN |
Proliferation, migration, invasion, | [57] | 2020 | |
|
Has-circ-0004680 circCCT3 |
Mir- 613 | Up |
CCT3 /WNT3/VGFR |
Metastasis | [101] | 2020 | |
|
Has _circ -001,900 circCAMSAP1 |
Mir328-5p Mir7 |
Up |
E2F1 EGFR IGF1R CAMSAP1 |
Promotes CRC progression | [102] | 2020 | |
| hsa_circ_0007534 | Up | Promotes proliferation and inhibits apoptosis | [93] | 2021 | |||
| Has-circ- 0,007,843 | Mir- 518-5p | Up | ARHGAP32 | Migration, invasion, | [103] | 2020 | |
| circRNA_100876 | miR-516b | Up | Inhibit proliferation and metastasis | [104] | 2020 | ||
| CircRNA_0000392 | miR-193a-5p | Up | PIK3R3/AKT | Promoter proliferation of CRC | [105] | 2020 | |
| circRNA_002144 | miR-615-5p | Up | LARP1 | Promotes growth and metastasis | [106] | 2020 | |
| Circ-Erbin | miR-125a-5p and miR-138-5p, | Up | 4EBP-1 | Promotes growth and metastasis of CRC | [107] | 2020 | |
| CircRNA 100,146 | miR-149 | Up | HMGA2 | Promotes Colorectal Cancer Progression | [108] | 2020 | |
| circ-NSUN2 | Up | IGF2BP2/HMGA2 | Promotes CRC liver metastasis | [109] | 2019 | ||
| circCCT3 | Mir613 | Up | VEGFA; WNT signaling | Contributes to metastases | [101] | 2019 | |
| Circ_0000218 | miR-139-3p | Up | RAB1A | Promoted CRC proliferation and metastasis via | [110] | 2019 | |
| circFMN2 | miR-1182 | Up | hTERT | Cell proliferation and migration | [111] | 2019 | |
| Circ 32,883 | Mir501-5p | Up | EmL5 | Promote resistance to folfox | [112] | 2019 | |
| Circ ACC1 | Up | c-Jun/AMPK | Promotes CRC cell fatty acid β-oxidation, glycolysis and growth | [113] | 2019 | ||
| hsa_circ_102958 | miR-585 | Up | CDC25B | Promotes CRC tumorigenesis | [114] | 2019 | |
| Has- circ-101555 | Mir 597-5p | Up |
CDK6 RPA3 |
Promote progression | [115] | 2019 | |
| Has-circ-0079993 | Mir 139-3p | Up | CREB1 | Promotes CRC cell proliferation | [116] | 2019 | |
| Has-circ- PIP5K1A |
Mir1273 Irf4 cdx2 ZIC1 |
Up | Promote progression CRC | [117] | 2019 | ||
| hsa_circ_0055625 | ITGB8 | Up | miR-106b | Increases colon cancer cell growth was associated with pathological TNM stage and metastasis | [118] | 2019 | |
| hsa_circ_0136666 |
PRKDC SH2B1 |
Up | Mir136 | Promote proliferation and invasion | [41] | 2019 | |
| hsa_circ_0073195 | miR-199-b | Up | Ddr1 and Jag1 signaling | Promotes metastasis | [97] | 2019 | |
| hsa_circ_0071589 | MIR-600 | Up |
Fat1 EZH2 |
Promotes carcinogenesis tumor growth, invasion, and migration | [119] | 2018 | |
| circRNA_100290 |
FZD4 SLC30A7 WNT/β-catenin |
Up | Mir516b | Promotes colorectal cancer | [120] | 2018 | |
| Cirs7 | miR-7 | Up | EGFR and IGF1R | Promotes progression | [27, 121] | 2017 | |
| Circ0000504 | Mir485-5p | Up |
Tubgcp3 Stat3 |
Promote resistance to 5fu | [122] | 2017 | |
| hsa_circ_000984 | CDK6 | Up | Mir 106b | Promotes cells proliferation and metastasis | [100] | 2017 | |
|
hsa_circ_0020397 (circBANP) |
DOCK1 PD_L1 TERT |
Up | Mir138 | Can regulate CRC cell viability, apoptosis, and invasion | [123] | 2017 | |
| Circ-0001313 |
miR-3383p 33b5p 935p |
Up | Ccdc66 | Promote resistance to radiotherapy and 5fu | [124] |
2019 2017 |
|
| Has-circ-001569 | miR145 | Up |
ABC1 E2f5 BAG4 |
The regulator in cell proliferation and invasion | [125] | 2016 | |
| circ_0007142 | miR-122-5p | Down | CDC25A | Proliferation, colony formation, migration, and invasion | [48] | 2020 | |
| CircCSNK1G1 | miR-455-3p | Down | MYO6 | Proliferation, migration and invasion cell growth and metastasis, | [126] | 2020 | |
| CircTADA2A | miR-374a-3p. MiR-374a-3p | Down | KLF14 | Tumor suppressor in CRC | [127] | 2020 | |
| circ-SMAD7 | Down | circ-SMAD7 could inhibit cell migration and invasion of CRC by suppressing the EMT process, | [128] | 2020 | |||
| Circ_cse1l | Down |
eIF4A3 PCNA |
circ_cse1l inhibited the proliferation of CRC | [129] | 2020 | ||
| ITGA5 circRNA | miR-107, | Down | FOXJ3 | Act as a tumor suppressor in CRC | [130] | 2020 | |
| CircDDX17 | miR-31-5p/ | Down | KANK1 |
Tumor suppressor blocked CRC progression Strengthened chemosensitivity of CRC to 5-Fu |
[131] | 2020 | |
| Hsa_circ_0137008 | microRNA-338-5p | Down | Inhibited the progression of CRC | [132] | 2020 | ||
| CircNOL10 | miR-135a-5p; miR-135b-5p | Down | KLF9 | Mediating proliferation, cell cycle, migration, and invasion | [133] | 2020 | |
| circ_0021977 | miR-10b-5p | Down | P21; P53 | Suppresses proliferation, migration, and invasion by CRC cells | [47] | 2020 | |
| circRNACBL11 | YWHAE | Up | Mir6778-5p | Suppress cell proliferation | [134] | 2019 | |
| Circ. CDYL |
c-Myc cyclin D1 |
Down | miR-150-5p/ | Inhibits CRC cell growth and migration | [135] | 2019 | |
| circITGA7 |
ITGA7 REB1 Ras’s pathway ASXL1 |
Down |
miR-370-3p mir-3187-3p |
Inhibits colorectal cancer growth and metastasis |
[44] [45] |
2019 2018 |
|
| hsa_circ_0009361 | Mir582-3p | Down | APC2/Wnt/β-catenin | Inhibits CRC progression | [43] | 2019 | |
| hsa_circ_0000523 |
METTL3 dKK1 WNT/β-catenin |
Down | Mir-31 |
Correlated to the tumorigenesis- Proliferation |
[136] | 2018 | |
| circITCH |
DDX17 WNT/β-catenin |
Down | miR-7, miR-17, miR-214 | Proliferation ( −) | [31] | 2015 | |