Table 2.
The characteristics of circRNAs in CRC as a chemotherapy resistance
| CircRNA | GENE related miRNA | Expression | Targeted molecules/pathways | Function | References (DOI) | Year |
|---|---|---|---|---|---|---|
| Hsa_circ_0079662 | Up |
TNF-α HOXA9 |
Induces the resistance mechanism of the chemotherapy drug oxaliplatin through the TNF‐α pathway | [66] | 2020 | |
| Hsa_circ_0005963 | miR-122 | Up | PKM2 | chemoresistance. In vitro and in vivo | [69] | 2020 |
| Circ_0007031 | miR-760 | Up | DCP1A | Regulate the Growth and Chemoradiotherapy Resistance | [84] | 2020 |
| CircDDX17 | miR-31-5p | Down | KANK1 |
Tumor suppressor Strengthened chemosensitivity of CRC to 5-Fu |
[131] | 2020 |
| Circ-PRKDC | miR-375 | Up | FOXM1 Axis and WBT/β-Catenin | Enhanced 5-FU resistance in CRC | [85] | 2020 |
| Circ-0001313 |
mir-3383p mir33b5p mir935p |
Up | Ccdc66 | Promote resistance to radiotherapy and 5fu | [124] | 2019 |
| Circ 32,883 | Mir501-5p | Up | EmL5 | Promote resistance to folfox | 2019 | |
| Circ0007006 |
Mir300 653-5p 628-5p |
Up | Promote resistance to 5fu | [122] | 2017 | |
| Circ0000504 | Mir485-5p | Up |
Tubgcp3 Stat3 |
Promote resistance to 5fu | [122] | 2017 |