Table 3.

circRNAs with Biomarker potential in CRC

CircRNA	GENE related miRNA	Expression	Targeted molecules/pathways	Function	References (DOI)
Hsa_circ_0002320		Down		Noninvasive diagnostic blood biomarker for CRC prognosis	[140]	2020
circMBOAT2	miR-519d-3p	Up tissues serum	TROAP)	A novel tumor marker and regulates proliferation/migration	[141]	2020
hsa_circ_0060927		Up		Potential diagnostic markers	[142]	2020
circ-CCDC66	miR-33b/miR-93/	Up	DNMT3B/EZH2/ MYC/YAP1	Promoting CRC growth and metastasis	[91]	2020
circ_0005075		Up	Wnt/β-catenin pathway	Potential target for the prognosis biomarker	[143]	2020
Hsa_circ_0004831		Up	WNT and p53 signaling pathway	Prognostic biomarker	[144]	2020
hsa_circ_104916		Down		Prognosis biomarker Inhibiting CRC cell proliferation, migration, invasion, and inducing apoptosis	[145]	2019
hsa_circ_0004585		Up		Potential diagnostic biomarker for CRC	[146]	2019
hsa-circ-0004771		Up		Nvel potential diagnostic biomarker	[147]	2019
circ-PPP1R12A Has-circ- 000,423		Up	Hippo/YAP Prognosis	Prognostic biomarker Promoting pathogenesis and metastasis	[148]	2019
circ-MTO1		Down	WNT/β-catenin	Prognostic biomarker, Inhibiting cell proliferation and invasion	[149]	2018
hsa_circ_0001649	SHARE	Down		Novel diagnostic biomarker Expression level is closely associated with pathological differentiation	[150]	2018
Has _circ_ 14,717		Down	P16	Prognostic biomarker Inhibiting CRC cell proliferation, colony formation, and growth	[151]	2018
hsa_circ_0026344	miR-21/miR-31	Down		Prognostic biomarker Inhibiting CRC cell growth and invasion and induces apoptosis	[45]	2018
Has-circ-0000711		Down		Diagnostic Prognostic biomarker	[152]	2018
Cirs-7	CDR1 EGFR/RAF1/MAPK pathway	Up	Mir-7	Prognostic biomarker	[27]	2018
hsa_circ_0000567	SETD3	Down			[153]	2018
hsa_circ_001988	FBXW7	Down		Potential diagnostic biomarker	[42]	2015
hsa_circ_0003906		Down		Diagnostic biomarker	[154]]	2015