Table 2.
Aggressive | Standard | Whole cohort | ||||
---|---|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | HR (95% CI) | P value | |
Age (years) | 0.99 (0.96–1.03) | 0.69 | 1.03 (1.00–1.07) | 0.04 | 1.01 (0.99–1.03) | 0.35 |
Sex (Female) | 1.17 (0.63–2.18) | 0.62 | 1.4 (0.78–2.5) | 0.26 | 1.29 (0.84–1.96) | 0.25 |
Persistent AF | 1.06 (0.62–1.81) | 0.83 | 0.75 (0.43–1.3) | 0.3 | 1.13 (0.77–1.66) | 0.54 |
Duration of AF | 1.00 (0.99–1.01) | 0.81 | 1.00 (1.00–1.01) | 0.07 | 1.00 (1.00–1.01) | 0.29 |
Baseline SBP (mmHg) | 1.03 (1.00–1.05) | 0.02 | 1.01 (0.99–1.03) | 0.38 | 1.02 (1.00–1.03) | 0.02 |
Baseline SBP ≥ 140 mmHg | 2.14 (1.22–3.73) | 0.01 | 0.83 (0.48–1.43) | 0.49 | 0.76 (0.51–1.11) | 0.15 |
Diabetes | 0.76 (0.34–1.67) | 0.49 | 1.58 (0.71–3.51) | 0.26 | 1.04 (0.59–1.82) | 0.89 |
LA Size | 1 (0.95–1.05) | 0.91 | 0.99 (0.94–1.04) | 0.74 | 0.99 (0.96–1.03) | 0.74 |
Baseline NT-proBNP ≥ 280 (pg/ml) | 1.98 (1.13–3.51) | 0.02 | 1.00 (0.55–1.83) | 0.99 | 1.40 (0.92–2.12) | 0.10 |
Log-NT-proBNP (pg/ml) | 1.28 (1.01–1.62) | 0.04 | 0.94 (0.74–1.20) | 0.62 | 1.09 (0.92–1.29) | 0.31 |
CRP | 1.00 (0.95–1.05) | 0.89 | 0.99 (0.92–1.07) | 0.82 | 1.00 (0.96–1.04) | 0.81 |
Significant results (p < 0.05) are bolded
All characteristics were measured at time of randomization
AF, atrial fibrillation; SBP, systolic blood pressure; LVEF, left ventricular ejection fraction; LA, left atrium; CRP, C-reactive protein