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. 2021 Sep 16;19:95. doi: 10.1186/s12964-021-00773-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — RRAS and RRAS2 differentially promote proliferation and migration in ST88-14 cells. a Real-time PCR assays for RRAS (left panel) and RRAS2 (right panel) mRNAs in ST88-14 cells transduced with lentiviruses expressing a non-targeting control shRNA (NT), RRAS shRNAs (RRasA, RRasB) or RRAS2 shRNAs (RRas2A, RRas2B). b RRAS and RRAS2 knockdown both potently inhibit the migration of ST88-14 MPNST cells. c RRAS2, but not RRAS, knockdown inhibits the proliferation of ST88-14 cells. d Both RRAS and RRAS2 knockdown inhibit the phosphorylation of MYPT1 and ROCK1. Quantification indicated below the blots represents the ratio of the normalized phosphorylated to total protein levels