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. 2005 Jan 24;2005(1):CD002738. doi: 10.1002/14651858.CD002738.pub2

Comparison 4. CFC‐BDP versus Placebo, not on oral steroids: all doses.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 FEV1 (L) 6 612 Mean Difference (IV, Fixed, 95% CI) 0.36 [0.22, 0.49]
1.4 400 mcg/day or less 2 213 Mean Difference (IV, Fixed, 95% CI) 0.34 [0.11, 0.56]
1.5 500 to 800 mcg/day 2 320 Mean Difference (IV, Fixed, 95% CI) 0.33 [0.14, 0.52]
1.6 1000 mcg/day or greater 2 79 Mean Difference (IV, Fixed, 95% CI) 0.48 [0.15, 0.82]
2 FEV1 (% predicted) 7 198 Mean Difference (IV, Random, 95% CI) 5.36 [‐0.88, 11.60]
2.4 400 mcg/day or less 2 44 Mean Difference (IV, Random, 95% CI) 3.80 [‐4.70, 12.31]
2.5 500 to 800 mcg/day 2 91 Mean Difference (IV, Random, 95% CI) 12.39 [‐1.57, 26.34]
2.6 1000 mcg/day or greater 3 63 Mean Difference (IV, Random, 95% CI) 0.00 [‐5.25, 5.25]
3 Change in FEV1 (L) 2 370 Mean Difference (IV, Fixed, 95% CI) 0.36 [0.26, 0.46]
3.1 BDP 400 mcg/day or less 2 370 Mean Difference (IV, Fixed, 95% CI) 0.36 [0.26, 0.46]
3.2 BDP 500 to 800 mcg/day 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
3.3 BDP 1000 mcg/day or greater 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
5 Morning PEFR (L/min) 2 78 Mean Difference (IV, Fixed, 95% CI) 46.52 [‐15.18, 108.21]
5.1 400 mcg/day or less 1 24 Mean Difference (IV, Fixed, 95% CI) 33.0 [‐82.62, 148.62]
5.3 500 to 800 mcg/day 1 54 Mean Difference (IV, Fixed, 95% CI) 51.90 [‐21.05, 124.85]
5.4 1000 mcg/day or greater 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
6 Change in morning PEF (L/min) 4 1112 Mean Difference (IV, Fixed, 95% CI) 39.05 [31.95, 46.15]
6.1 400 mcg/day or less 3 878 Mean Difference (IV, Fixed, 95% CI) 35.95 [27.85, 44.04]
6.2 500‐800mcg/day or less 1 234 Mean Difference (IV, Fixed, 95% CI) 49.4 [34.62, 64.18]
6.3 1000 mcg/day or greater 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
7 FVC (L) 2 114 Mean Difference (IV, Fixed, 95% CI) 0.22 [‐0.16, 0.60]
7.1 BDP 400 mcg/day or less 1 28 Mean Difference (IV, Fixed, 95% CI) 0.28 [‐0.47, 1.03]
7.2 BDP 500 to 800 mcg/day 1 86 Mean Difference (IV, Fixed, 95% CI) 0.20 [‐0.23, 0.63]
7.3 1000 mcg/day or greater 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
9 Methacholine bronchial responsiveness (log 10 values) 5 89 Std. Mean Difference (IV, Fixed, 95% CI) 0.53 [0.10, 0.96]
9.3 400 mcg/day or less 3 51 Std. Mean Difference (IV, Fixed, 95% CI) 0.53 [‐0.04, 1.10]
9.4 500 to 800 mcg/day 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
9.5 1000 mg/day or greater 2 38 Std. Mean Difference (IV, Fixed, 95% CI) 0.53 [‐0.12, 1.18]
10 FEF25‐75% (L/Second) 2 110 Mean Difference (IV, Fixed, 95% CI) 0.93 [0.58, 1.28]
10.1 400 mcg/day or less 1 24 Mean Difference (IV, Fixed, 95% CI) 4.6 [3.60, 5.60]
10.2 500‐800 mcg/day 1 86 Mean Difference (IV, Fixed, 95% CI) 0.42 [0.05, 0.79]
10.3 1000 mcg/day or greater 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
12 Daily asthma symptom score 2 38 Std. Mean Difference (IV, Random, 95% CI) ‐2.81 [‐3.77, ‐1.86]
12.1 400 mcg/day or less 0 0 Std. Mean Difference (IV, Random, 95% CI) 0.0 [0.0, 0.0]
12.3 500 to 800 mcg/day 1 18 Std. Mean Difference (IV, Random, 95% CI) ‐2.57 [‐3.90, ‐1.25]
12.4 1000 mcg/day or greater 1 20 Std. Mean Difference (IV, Random, 95% CI) ‐3.07 [‐4.44, ‐1.69]
13 Daily asthma symptoms score (change from baseline) 2 611 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.19 [‐0.35, ‐0.03]
13.1 400 mcg/day or less 1 508 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.13 [‐0.30, 0.05]
13.2 500‐800 mcg/day 1 103 Std. Mean Difference (IV, Fixed, 95% CI) ‐0.55 [‐0.95, ‐0.15]
13.3 1000 mcg/day or greater 0 0 Std. Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
14 Daily use of beta2 agonists (puffs/day) 3 294 Mean Difference (IV, Fixed, 95% CI) ‐1.98 [‐2.34, ‐1.62]
14.1 400 mcg/day or less 1 256 Mean Difference (IV, Fixed, 95% CI) ‐0.95 [‐1.45, ‐0.45]
14.3 500 to 800 mcg/day 1 18 Mean Difference (IV, Fixed, 95% CI) ‐3.4 [‐4.79, ‐2.01]
14.4 1000 mcg/day or greater 1 20 Mean Difference (IV, Fixed, 95% CI) ‐3.0 [‐3.55, ‐2.45]
15 Change in rescue beta‐agonist use 3 856 Mean Difference (IV, Fixed, 95% CI) ‐2.18 [‐2.38, ‐1.97]
15.1 400 mcg/day or less 2 622 Mean Difference (IV, Fixed, 95% CI) ‐2.32 [‐2.55, ‐2.09]
15.2 500‐800 mcg/day 1 234 Mean Difference (IV, Fixed, 95% CI) ‐1.64 [‐2.08, ‐1.20]
15.3 1000 mcg/day or greater 0 0 Mean Difference (IV, Fixed, 95% CI) 0.0 [0.0, 0.0]
16 Withdrawal due to asthma exacerbation 15 1185 Risk Ratio (M‐H, Fixed, 95% CI) 0.25 [0.16, 0.39]
16.4 400 mcg/day or less 9 928 Risk Ratio (M‐H, Fixed, 95% CI) 0.29 [0.18, 0.48]
16.5 500 to 800 mcg/day 2 117 Risk Ratio (M‐H, Fixed, 95% CI) 0.34 [0.09, 1.30]
16.6 1000 mcg/day or greater 4 140 Risk Ratio (M‐H, Fixed, 95% CI) 0.03 [0.00, 0.53]
17 Oral candidiasis 4 392 Risk Ratio (M‐H, Fixed, 95% CI) 1.17 [0.41, 3.33]
17.1 400 mcg/day or less 2 259 Risk Ratio (M‐H, Fixed, 95% CI) 3.75 [0.62, 22.57]
17.2 500‐800 mcg/day 1 93 Risk Ratio (M‐H, Fixed, 95% CI) 0.11 [0.01, 2.05]
17.3 1000 mcg/day or greater 1 40 Risk Ratio (M‐H, Fixed, 95% CI) 3.0 [0.13, 69.52]
18 Oropharyngeal side‐effects 5 623 Risk Ratio (M‐H, Fixed, 95% CI) 1.30 [0.73, 2.33]
18.1 400 mcg/day or less 2 276 Risk Ratio (M‐H, Fixed, 95% CI) 1.54 [0.25, 9.54]
18.4 500 to 800 mcg/day 1 93 Risk Ratio (M‐H, Fixed, 95% CI) 0.11 [0.01, 2.05]
18.5 1000 mcg/day or greater 2 254 Risk Ratio (M‐H, Fixed, 95% CI) 1.71 [0.88, 3.35]