1 FEV1 (L) |
6 |
612 |
Mean Difference (IV, Fixed, 95% CI) |
0.36 [0.22, 0.49] |
1.4 400 mcg/day or less |
2 |
213 |
Mean Difference (IV, Fixed, 95% CI) |
0.34 [0.11, 0.56] |
1.5 500 to 800 mcg/day |
2 |
320 |
Mean Difference (IV, Fixed, 95% CI) |
0.33 [0.14, 0.52] |
1.6 1000 mcg/day or greater |
2 |
79 |
Mean Difference (IV, Fixed, 95% CI) |
0.48 [0.15, 0.82] |
2 FEV1 (% predicted) |
7 |
198 |
Mean Difference (IV, Random, 95% CI) |
5.36 [‐0.88, 11.60] |
2.4 400 mcg/day or less |
2 |
44 |
Mean Difference (IV, Random, 95% CI) |
3.80 [‐4.70, 12.31] |
2.5 500 to 800 mcg/day |
2 |
91 |
Mean Difference (IV, Random, 95% CI) |
12.39 [‐1.57, 26.34] |
2.6 1000 mcg/day or greater |
3 |
63 |
Mean Difference (IV, Random, 95% CI) |
0.00 [‐5.25, 5.25] |
3 Change in FEV1 (L) |
2 |
370 |
Mean Difference (IV, Fixed, 95% CI) |
0.36 [0.26, 0.46] |
3.1 BDP 400 mcg/day or less |
2 |
370 |
Mean Difference (IV, Fixed, 95% CI) |
0.36 [0.26, 0.46] |
3.2 BDP 500 to 800 mcg/day |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
3.3 BDP 1000 mcg/day or greater |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
5 Morning PEFR (L/min) |
2 |
78 |
Mean Difference (IV, Fixed, 95% CI) |
46.52 [‐15.18, 108.21] |
5.1 400 mcg/day or less |
1 |
24 |
Mean Difference (IV, Fixed, 95% CI) |
33.0 [‐82.62, 148.62] |
5.3 500 to 800 mcg/day |
1 |
54 |
Mean Difference (IV, Fixed, 95% CI) |
51.90 [‐21.05, 124.85] |
5.4 1000 mcg/day or greater |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
6 Change in morning PEF (L/min) |
4 |
1112 |
Mean Difference (IV, Fixed, 95% CI) |
39.05 [31.95, 46.15] |
6.1 400 mcg/day or less |
3 |
878 |
Mean Difference (IV, Fixed, 95% CI) |
35.95 [27.85, 44.04] |
6.2 500‐800mcg/day or less |
1 |
234 |
Mean Difference (IV, Fixed, 95% CI) |
49.4 [34.62, 64.18] |
6.3 1000 mcg/day or greater |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
7 FVC (L) |
2 |
114 |
Mean Difference (IV, Fixed, 95% CI) |
0.22 [‐0.16, 0.60] |
7.1 BDP 400 mcg/day or less |
1 |
28 |
Mean Difference (IV, Fixed, 95% CI) |
0.28 [‐0.47, 1.03] |
7.2 BDP 500 to 800 mcg/day |
1 |
86 |
Mean Difference (IV, Fixed, 95% CI) |
0.20 [‐0.23, 0.63] |
7.3 1000 mcg/day or greater |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
9 Methacholine bronchial responsiveness (log 10 values) |
5 |
89 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.53 [0.10, 0.96] |
9.3 400 mcg/day or less |
3 |
51 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.53 [‐0.04, 1.10] |
9.4 500 to 800 mcg/day |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
9.5 1000 mg/day or greater |
2 |
38 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.53 [‐0.12, 1.18] |
10 FEF25‐75% (L/Second) |
2 |
110 |
Mean Difference (IV, Fixed, 95% CI) |
0.93 [0.58, 1.28] |
10.1 400 mcg/day or less |
1 |
24 |
Mean Difference (IV, Fixed, 95% CI) |
4.6 [3.60, 5.60] |
10.2 500‐800 mcg/day |
1 |
86 |
Mean Difference (IV, Fixed, 95% CI) |
0.42 [0.05, 0.79] |
10.3 1000 mcg/day or greater |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
12 Daily asthma symptom score |
2 |
38 |
Std. Mean Difference (IV, Random, 95% CI) |
‐2.81 [‐3.77, ‐1.86] |
12.1 400 mcg/day or less |
0 |
0 |
Std. Mean Difference (IV, Random, 95% CI) |
0.0 [0.0, 0.0] |
12.3 500 to 800 mcg/day |
1 |
18 |
Std. Mean Difference (IV, Random, 95% CI) |
‐2.57 [‐3.90, ‐1.25] |
12.4 1000 mcg/day or greater |
1 |
20 |
Std. Mean Difference (IV, Random, 95% CI) |
‐3.07 [‐4.44, ‐1.69] |
13 Daily asthma symptoms score (change from baseline) |
2 |
611 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.19 [‐0.35, ‐0.03] |
13.1 400 mcg/day or less |
1 |
508 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.13 [‐0.30, 0.05] |
13.2 500‐800 mcg/day |
1 |
103 |
Std. Mean Difference (IV, Fixed, 95% CI) |
‐0.55 [‐0.95, ‐0.15] |
13.3 1000 mcg/day or greater |
0 |
0 |
Std. Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
14 Daily use of beta2 agonists (puffs/day) |
3 |
294 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.98 [‐2.34, ‐1.62] |
14.1 400 mcg/day or less |
1 |
256 |
Mean Difference (IV, Fixed, 95% CI) |
‐0.95 [‐1.45, ‐0.45] |
14.3 500 to 800 mcg/day |
1 |
18 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.4 [‐4.79, ‐2.01] |
14.4 1000 mcg/day or greater |
1 |
20 |
Mean Difference (IV, Fixed, 95% CI) |
‐3.0 [‐3.55, ‐2.45] |
15 Change in rescue beta‐agonist use |
3 |
856 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.18 [‐2.38, ‐1.97] |
15.1 400 mcg/day or less |
2 |
622 |
Mean Difference (IV, Fixed, 95% CI) |
‐2.32 [‐2.55, ‐2.09] |
15.2 500‐800 mcg/day |
1 |
234 |
Mean Difference (IV, Fixed, 95% CI) |
‐1.64 [‐2.08, ‐1.20] |
15.3 1000 mcg/day or greater |
0 |
0 |
Mean Difference (IV, Fixed, 95% CI) |
0.0 [0.0, 0.0] |
16 Withdrawal due to asthma exacerbation |
15 |
1185 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.25 [0.16, 0.39] |
16.4 400 mcg/day or less |
9 |
928 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.29 [0.18, 0.48] |
16.5 500 to 800 mcg/day |
2 |
117 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.34 [0.09, 1.30] |
16.6 1000 mcg/day or greater |
4 |
140 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.03 [0.00, 0.53] |
17 Oral candidiasis |
4 |
392 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.17 [0.41, 3.33] |
17.1 400 mcg/day or less |
2 |
259 |
Risk Ratio (M‐H, Fixed, 95% CI) |
3.75 [0.62, 22.57] |
17.2 500‐800 mcg/day |
1 |
93 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.11 [0.01, 2.05] |
17.3 1000 mcg/day or greater |
1 |
40 |
Risk Ratio (M‐H, Fixed, 95% CI) |
3.0 [0.13, 69.52] |
18 Oropharyngeal side‐effects |
5 |
623 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.30 [0.73, 2.33] |
18.1 400 mcg/day or less |
2 |
276 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.54 [0.25, 9.54] |
18.4 500 to 800 mcg/day |
1 |
93 |
Risk Ratio (M‐H, Fixed, 95% CI) |
0.11 [0.01, 2.05] |
18.5 1000 mcg/day or greater |
2 |
254 |
Risk Ratio (M‐H, Fixed, 95% CI) |
1.71 [0.88, 3.35] |