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. 2005 Jan 24;2005(1):CD002738. doi: 10.1002/14651858.CD002738.pub2

Davies 1977.

Methods Setting: Canada, hospital outpatient clinic 
 Length of intervention period: 12 weeks 
 Randomisation: yes, computer generated sequence 
 Allocation concealment: yes 
 Design: parallel 
 Masking: double blind 
 Excluded: not stated 
 Withdrawals: not stated 
 Baseline characteristics: comparable 
 Jadad score: 4
Participants 33 adults: 15M 18F 
 Mean age: 55 (BDP group) 43 (placebo group) 
 Inclusion criteria: 
 Requiring oral steroid treatment for asthma control for 1 year or longer 
 15% or greater improvement in FEV1 after inhaled beta2 agonist 
 Exclusion criteria: 
 Chronic atopic eczema or a history of chronic bronchitis as defined by ATS criteria.
Interventions BDP 50mcg 2 pfs 4x daily (400mcg/d)
Placebo 2 pfs 4xdaily
Delivery device: MDI
Outcomes FEV1 (% predicted) 
 Daytime asthma symptom score 
 Nighttime asthma symptom score 
 Daily dose oral prednisolone 
 Daily beta2 agonist use 
 Blood eosinophil count 
 2 pm serum cortisol
Notes Reply from authors clarifying method of random order generation and that allocation concealment was employed.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Low risk A ‐ Adequate
HHS Vulnerability Disclosure