Harvey 1976.
Methods | Setting: USA, hospital outpatient clinic Length of intervention period: 12 weeks Randomisation: yes method not stated Allocation concealment: unclear Design: parallel group Masking: double blind Excluded: not stated Withdrawals: stated Baseline characteristics: comparable Jadad score: 4 | |
Participants | 34 adolescents/adults: 11M 23F Age range: 14 to 75 years Inclusion criteria: Asthmatic patients dependent on oral steroids for at least 6 months, not exceeding 20mg per day. Exclusion criteria: Pregnancy Concurrent severe disease | |
Interventions | BDP: 50mcg 2 pfs 4xdaily (400mcg/d) Placebo: 2 pfs 4xdaily Delivery device: MDI |
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Outcomes | % change in FEV1 % change in FEF 50 Daily oral prednisolone dose 8am plasma cortisol Discontinuation of oral steroids (number of patients) | |
Notes | No reply from author to clarify details of randomisation method. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Allocation concealment? | Unclear risk | B ‐ Unclear |