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. 2005 Jan 24;2005(1):CD002738. doi: 10.1002/14651858.CD002738.pub2

Harvey 1976.

Methods Setting: USA, hospital outpatient clinic 
 Length of intervention period: 12 weeks 
 Randomisation: yes method not stated 
 Allocation concealment: unclear 
 Design: parallel group 
 Masking: double blind 
 Excluded: not stated 
 Withdrawals: stated 
 Baseline characteristics: comparable 
 Jadad score: 4
Participants 34 adolescents/adults: 11M 23F 
 Age range: 14 to 75 years 
 Inclusion criteria: 
 Asthmatic patients dependent on oral steroids for at least 6 months, not exceeding 20mg per day. 
 Exclusion criteria: 
 Pregnancy 
 Concurrent severe disease
Interventions BDP: 50mcg 2 pfs 4xdaily (400mcg/d)
Placebo: 2 pfs 4xdaily
Delivery device: MDI
Outcomes % change in FEV1 
 % change in FEF 50 
 Daily oral prednisolone dose 
 8am plasma cortisol 
 Discontinuation of oral steroids (number of patients)
Notes No reply from author to clarify details of randomisation method.
Risk of bias
Bias Authors' judgement Support for judgement
Allocation concealment? Unclear risk B ‐ Unclear