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. 2021 Sep 3;12:679773. doi: 10.3389/fmicb.2021.679773

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Copyright © 2021 Chandhni, Pradhan, Sowmya, Gupta, Kadyan, Choudhary, Gupta, Gulati, Mallappa, Kaushik and Grover.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Changes in mean colon length of the different mice groups; (B) Histopathology-based colitis scores of different mice groups; (C) Gross morphology of the colons of mice from different groups used to measure severity of disease (n = 8); 1, Intact surface epithelium; 2, Intact crypts; 3, Preserved goblet cells; 4, Erosion of surface epithelium; 5, Infiltration of lamina propria; 6, Crypt abscess; 7, Mild erosion of surface epithelium; 8, Mild loss of goblet cells; 9, Crypt abscess; 10, Mild erosion of surface epithelium; 11, Moderate loss of goblet cells with shortened crypts; 12, Normal colonic mucosa and surface epithelium; 13, Crypt branching with mild loss of goblet cells. *P < 0.05; **P < 0.01.