TABLE 3.
Prognostic factors in patients with small cell lung carcinoma
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| Exp. (95% CI) | p‐value | Exp. (95% CI) | p‐value | |
| Age (years) | ||||
| ≤49 | 1.000 | 1.000 | ||
| 50–59 | 1.195 (0.703–2.032) | 0.511 | 1.726 (0.686–4.343) | 0.246 |
| 60–69 | 1.344 (0.806–2.243) | 0.257 | 1.911 (0.766–4.766) | 0.165 |
| ≥70 | 2.114 (1.280–3.491) | 0.003** | 3.200 (1.297–7.896) | 0.012* |
| Sex | ||||
| Male | 1.000 | |||
| Female | 0.903 (0.724–1.127) | 0.368 | ||
| BMI (kg/m2) | ||||
| <18.5 | 1.715 (1.287–2.286) | <0.001*** | 1.443 (0.895–2.325) | 0.132 |
| 18.5–22.9 | 1.000 | 1.000 | ||
| 23–24.9 | 0.858 (0.693–1.602) | 0.159 | 0.883 (0.657–2.325) | 0.411 |
| 25–29.9 | 0.694 (0.563–0.854) | 0.001** | 0.719 (0.546–0.946) | 0.019* |
| ≥30 | 0.842 (0.527–1.344) | 0.471 | 0.491 (0.239–1.009) | 0.053 |
| Smoking habit | ||||
| Never‐smoker | 1.000 | |||
| Current smoker | 0.670 (0.537–0.836) | <0.001*** | ||
| Ex‐smoker | 0.675 (0.531–0.856) | 0.001** | ||
| ECOG PS | ||||
| 0 | 1.000 | 1.000 | ||
| 1 | 1.020 (0.832–1.250) | 0.852 | 0.928 (0.723–1.190) | 0.555 |
| 2 | 1.865 (1.361–2.556) | <0.001*** | 1.925 (1.292–2.868) | 0.001** |
| 3 | 2.683 (1.692–4.257) | <0.001*** | 1.496 (0.678–3.298) | 0.318 |
| 4 | 3.419 (2.033–5.748) | <0.001*** | 2.709 (1.067–6.879) | 0.036* |
| Clinical stage | ||||
| Limited disease | 1.000 | 1.000 | ||
| Extensive disease | 2.145 (1.805–2.548) | <0.001*** | 2.142 (1.688–2.717) | <0.001*** |
| Lung function group | ||||
| Normal | 1.000 | 1.000 | ||
| COPD | 1.439 (1.097–1.886) | 0.008** | 1.240 (0.912–1.685) | 0.169 |
| PRISm | 1.864 (1.385–2.510) | <0.001*** | 1.629 (1.166–2.275) | 0.004** |
Abbreviations: BMI, body mass index; COPD, chronic obstructive pulmonary disease; ECOG PS, Eastern Cooperative Oncology Group Performance Status; PRISm, preserved ratio impaired spirometry.
*p < 0.05, **p < 0.01, ***p < 0.001.