Table 2.
Selected markers and their regulation within murine (left) and human (right) TAM-MG and TAM-MDMs.
| Category | Target (depending on study, referred to gene or protein) | Mouse | Human | ||
|---|---|---|---|---|---|
| TAM-MG | TAM-MDM | TAM-MG | TAM-MDM | ||
| Microglia lineage | CX3CR1 | (28, 30, 32) | (30, 32) | (28, 29) | (27, 29) |
| P2RY12 | (28, 30, 32) | (30, 32) | (28, 29) | (29) | |
| SALL1 | (30, 32) | Slightly up (30, 32) | (29) | Low (29) | |
| TMEM119 | (28, 30, 32) | (30, 32) | (28, 29) | Unchanged (29) | |
| Macrophage lineage | CCR2 | Lower in MG (30, 32) | Higher in MDM (30, 32) | Lower in MG (27, 29) | Higher in MDM but downregulated (27) or upregulated (29) |
| CD49d | Lower in MG (30, 32) | Higher in MDM (30, 32) | Lower in MG (27, 29) | Higher in MDM (27, 29) | |
| Antigen presentation | H2-Aa (only mouse) | Lower than MDM, but upregulated (30, 32) | Higher than MG (28, 30, 32) | ||
| H2-Ab (only mouse) | Lower than MDM, but upregulated (30, 32) | Higher than MG (28, 30, 32) | |||
| H2-Eb (only mouse) | Lower than MDM, but upregulated (30, 32) | Higher than MG (28, 30, 32) | |||
| H2-D1 (only mouse) | (30, 32) | Strongly upregulated (30), slightly regulated (32) | |||
| B2M | (30, 32) | (30, 32) (higher than MG) | Strong upregulation (29) | Slight upregulation and higher than MG (32) | |
| HLA-A (only human) | (29) | (29) | |||
| HLA-DR (only human) | (27) [high but slightly decreased expression in (29)] | Higher presence than MG (27, 29) | |||
| CD74 | (30, 32) | Higher than MG (28, 30, 32) | Slight downregulation (29) | (29) | |
| T cell interaction | CD275/ICOSLG/B7-H2 | Unchanged (30) or slightly upregulated (32) | Upregulated (30, 32) | No expression change (29) | (29) |
| PD-L1 | Unchanged (30) or slightly upregulated (32) | Higher than MG (28, 30, 32) | No expression change but higher than MDM (27, 29) | Upregulated in MDM-3 (27), no expression change (29) | |
| Complement | C1Q | (28, 30, 32) (but higher than MDM) | (28, 30, 32) | Slight downregulation (29) | (29) C1QB high (31) |
| C3 | (30, 32) | Unchanged (30) or slightly upregulated (32) | (28, 29) | (29) | |
| C3AR1 | (30, 32) | (30, 32) | (29) | Strong upregulation (29) | |
| C4B | (30, 32) | (30, 32) | Slight upregulation (29) | Slight upregulation (29) | |
| C5AR1 | (30, 32) | (30, 32) | Slight downregulation (29) | Slight downregulation (29) | |
| Cytokine | CCL2 | (30, 32) | (30, 32) | (29) | Unchanged (29) |
| CCL3 | (30, 32) | (30, 32) | (29) | Strong upregulation (29), high expression (31) | |
| CCL4 | (30, 32) | (30, 32) | (29) | Strong upregulation (29), high expression (31) | |
| IL1A | (30, 32) | (30, 32) | Slight downregulation, high level (29) | Strong upregulation (29) | |
| IL1B | (30, 32) | (28, 30, 32) | Slight downregulation, high level (29) | Strong upregulation (29), high expression (31) | |
| TNF | (30, 32) | (30, 32) | Slight downregulation, high level (29) | Strong upregulation (29) | |
| TAM signaling | AXL | (30, 32) | (30, 32) | (29) | (27, 29) |
| MERTK | Downregulated (30), unchanged (32) | (30, 32) | Moderate (27) | Partially (27) or strong upregulated (29) | |
| GAS6 | (30, 32) | (30, 32) | (29) | Strong upregulation (29) | |
| Growth factor and ECM organizer | APOE | (30, 32) (higher than MDM) | (28, 30, 32) | Mixed acc. to primary (29), higher expressed than MDM (31) | Unchanged/slightly downregulated (29) |
| CTSB | (30, 32) | (30, 32) | Unchanged (29) | Downregulated, but higher levels than MG (29) | |
| LGALS3 | (28, 30, 32) | Not regulated (30) or downregulated (32), higher than MG (28) | Strong upregulation (29) | Slightly downregulated, but higher than MG (29) | |
| SEMA4B | (30, 32) | Slightly up (30) or down (32) | (29) | (29) | |
| SPARC | Slightly upregulated (30, 32) | (30, 32) | Strong upregulation (29) | (29) | |
| VEGFA | Slightly upregulated (30, 32) | (30, 32) | Moderately upregulated (29) | Strong upregulation (29) | |
| Receptors | CD33/SIGLEC3 | Downregulated (30), unchanged high expression (32) | (30, 32) | Absent (27) | Down on protein level (27), up on RNA (29) |
| CD64/FCGR1 | Unchanged (30, 32) | Upregulated (30), no change (32) | (29) | (27, 29) | |
| CD163 | No expression (30, 32) | No expression (30), upregulated (32) | Low (27) or upregulated (29, 31) | (27, 29, 31) | |
| MARCO | No expression (30, 32) | No expression (30, 32) | Low expression (29) | Strong upregulation (29) | |
| NR4A2 | (30, 32) | (30) (slightly) (32), | (29) | Strong upregulation (29) | |
| CD206/MRC1 | Downregulated (30) or slightly upregulated (32) | (30, 32) | (29) | (27, 29, 31) | |
| P2RX4 | (30, 32) | (30, 32) | Unchanged high expression (29) | Slight downregulation (29) | |
| TREM2 | Slightly upregulated (30, 32) | Strongly upregulated (30, 32) | Slight downregulation (29) | Unchanged high expression (29) | |
| Others | CD209/CLEC4L | No expression (30) or slightly upregulated (32) | High expression (30, 32) | Low (27, 29) | High on MDM-3 (27) or downregulated (29) |
| MS4A family members | |||||
| MS4A4C | Slight upregulation (30, 32) | No change (30, 32), upregulated (28) | In H. sapiens: MS4A4E, low expression (29) | In H. sapiens: MS4A4E, strong upregulation (29) | |
| MS4A6C | (28, 30, 32) | Unchanged high expression (30, 32); slightly upregulated (28) | In H. sapiens: MS4A6E, low expression (29) | In H. sapiens: MS4A6E (29) | |
| MS4A7 | (30, 32) | High expression (30, 32) | Slight downregulation (29) | (29) | |
| S100A family members | |||||
| Higher then MDM in (28): S100a4, S100a6, S100a10 | S100a6, S100a10 (32) | (29): S100A4, S100A6 [high in (31)], S100A10 [high in (31)] | (29): high expression level but down in TAM-MDM (S100A4, S100A6) | ||
| Not expressed: S100a4 (30, 32), S100a6 (32); S100a10 [slightly down (32)] | (31): low expression of S100A8, S100A9 | (31): slight expression of S100A8, S100A9 | |||
| S100a6, S100a10 (30) | |||||
| S100A16 | Slightly upregulated (30), downregulated (32) | Upregulated (30), no expression (32) | (29): strong upregulation | (29): slight upregulation | |
| SPP1 | (30, 32) | (30, 32) | High expression, but unchanged in TAM-MG (29) | (29): slight upregulation | |
Red cell, upregulated; blue cell, downregulated; grey cell, comment within the corresponding cell. In addition, each cell contains information of the respective reference. Note that if not stated otherwise, up/downregulation is referring to the comparison of BrM-associated cells vs. their normal counterpart.