Table 3.
Results of mixed effects model comparing the concentration of biomarker at each timepoint for all participants to baseline values (Model 2)
| Estimated ratio (postoperative time point/baseline) | 95% confidence interval | P-value | |
|---|---|---|---|
| T-tau | |||
| 1 h post-induction | 2.19 | 1.62–2.95 | < 0.001 |
| 5 h post-induction | 1.06 | 0.78–1.43 | 0.716 |
| 24 h post-induction | 1.03 | 0.76–1.39 | 0.854 |
| P-tau181 | |||
| 1 h post-induction | 3.01 | 1.87–4.85 | <0.001 |
| 5 h post-induction | 0.95 | 0.58–1.54 | 0.827 |
| 24 h post-induction | 0.59 | 0.36–0.96 | 0.036 |
| NFL | |||
| 1 h post-induction | 1.10 | 1.00–1.21 | 0.048 |
| 5 h post-induction | 0.92 | 0.84–1.01 | 0.087 |
| 24 h post-induction | 0.94 | 0.86–1.04 | 0.212 |
Note: The exponentiated coefficient gives the estimated ratio of the concentration of biomarker at each timepoint compared to baseline. NFL: Neurofilament light; P-tau181: tau phosphorylated at threonine 181; T-tau: total tau.