Table 1.

The enriched GO terms and KEGG pathways for the down-regulated DEGs.

Category	Term	Description	Count	Genes	P value	FDR
BP	GO:0030198	Extracellular matrix organization	10	B4GALT1, COL7A1, FBN1, POSTN, COL1A1, LOX, COL8A1, LOXL1, ITGAM, COL5A1	1.38E-06	2.00E-03
BP	GO:0030574	Collagen catabolic process	7	COL7A1, MMP19, COL1A1, MMP14, COL8A1, MMP2, COL5A1	1.42E-06	2.00E-03
BP	GO:0002504	Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II	5	HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DRA	1.99E-06	3.00E-03
CC	GO:0031012	Extracellular matrix	13	ACTG1, HMCN1, COL7A1, MMP19, FBN1, POSTN, COL1A1, LOXL2, COL8A1, MMP14, MMP2, LOXL1, COL5A1	5.63E-08	6.95E-05
CC	GO:0030666	Endocytic vesicle membrane	7	WNT5B, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DRA, CD163	1.37E-06	2.00E-03
CC	GO:0042613	MHC class II protein complex	5	HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-DRA	5.13E-06	6.00E-03
MF	GO:0042605	Peptide antigen binding	6	HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, SLC7A5, HLA-DRA	4.27E-07	5.33E-04
KEGG	hsa05150	Staphylococcus aureus infection	8	C3AR1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, FCGR3A, ITGAM, HLA-DRA	1.87E-07	2.20E-04
KEGG	hsa05140	Leishmaniasis	8	IRAK1, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, FCGR3A, ITGAM, HLA-DRA	1.26E-06	1.49E-03
KEGG	hsa04145	Phagosome	9	ACTG1, ATP6V1A, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, FCGR3A, ITGAM, HLA-DRA	2.17E-05	2.55E-02

BPs = biological processes, DEGs = differentially-expressed genes, GO = gene ontology, MF = molecular function, MHC = major histocompatibility complex.