Table 4.
Genotype and minor allele frequencies and Hardy-Weinberg Equilibrium test for the analyzed variants in the total study sample (n=203), among cases (n=103), and among control subjects (n=100)
| Variant | Genotypes | Genotype frequencies, n | Minor allele frequency | HWE P* |
|---|---|---|---|---|
| Total sample | ||||
| rs2066842 (SNP5) | CC/CT/TT | 154/33/16 | 0.16 | <0.001 |
| rs2066844 (SNP8)† | CC/CT/TT | 202/1/0 | 0.003 | NA |
| rs2066845 (SNP12) | GG/GC/CC | 169/24/10 | 0.11 | <0.001 |
| rs2066847 (SNP13)† | Wild type/mutant | 203/0 | 0 | NA |
| Cases | ||||
| rs2066842 (SNP5) | CC/CT/TT | 86/11/6 | 0.11 | <0.001 |
| rs2066844 (SNP8)† | CC/CT/TT | 102/1/0 | 0.005 | NA |
| rs2066845 (SNP12) | GG/GC/CC | 79/14/10 | 0.17 | <0.001 |
| rs2066847 (SNP13)† | Wild type/mutant | 103/0 | 0 | NA |
| Controls | ||||
| rs2066842 (SNP5) | CC/CT/TT | 68/22/10 | 0.21 | 0.003 |
| rs2066844 (SNP8)† | CC/CT/TT | 100/0/0 | 0 | NA |
| rs2066845 (SNP12) | GG/GC/CC | 90/10/0 | 0.05 | 1.00 |
| rs2066847 (SNP13)† | Wild type/mutant | 100/0 | 0 | NA |
HWE: Hardy-Weinberg Equilibrium; NA: not applicable. † These variants were not analyzed due to their minor allele frequency being<1%. * P is testing the hypothesis that variants are in HWE