Table 5.
Associations between genetic variants rs2066842 (SNP5) and rs2066845 (SNP12) genotypes and the presence of Crohn’s disease, using co-dominant and dominant genetic risk models
| Variant | Genetic Model/Genotypes | Cases (n=103), % (n) | Controls (n=100), % (n) | Unadjusted OR (95% CI) | P | Adjusted OR* (95% CI) | P |
|---|---|---|---|---|---|---|---|
| Pro268Ser (SNP5) | Co-dominant | ||||||
| CC | 83.5 (86) | 68.0 (68) | 1.00 (Reference) | - | 1.00 (Reference) | - | |
| CT | 10.7 (11) | 22.0 (22) | 0.40 (0.18-0.87) | 0.021 | 0.42 (0.19-0.94) | 0.034 | |
| TT | 5.8 (6) | 10.0 (10) | 0.47 (0.16-1.37) | 0.168 | 0.45 (0.15-1.31) | 0.141 | |
| Dominant | |||||||
| CC | 83.5 (86) | 68.0 (68) | 1.00 (Reference) | - | 1.00 (Reference) | - | |
| CT+TT | 16.5 (17) | 32.0 (32) | 0.42 (0.22-0.82) | 0.011 | 0.43 (0.22-0.84) | 0.014 | |
| Gly908Arg (SNP12) | Co-dominant | ||||||
| GG | 76.7 (79) | 90.0 (90) | 1.00 (Reference) | - | 1.00 (Reference) | - | |
| GC | 13.6 (14) | 10.0 (10) | 1.60 (0.67-3.79) | 0.291 | 1.47 (0.61-3.56) | 0.392 | |
| CC | 9.7 (10) | 0.0 (0) | NE | - | NE | - | |
| Dominant | |||||||
| GG | 76.7 (79) | 90.0 (90) | 1.00 (Reference) | - | 1.00 (Reference) | - | |
| GC+CC | 23.3 (24) | 10.0 (10) | 2.73 (1.23-6.07) | 0.013 | 2.67 (1.19-5.97) | 0.018 |
OR: odds ratio; CI: confidence interval; NE: not estimable due to zero count. * Adjusted for sex