Table 6.

Associations of sociodemography and clinical characteristics of Kuwaiti CD patients with Pro268Ser (SNP5) and Gly908Arg (SNP12) mutations in the NOD2/Card15 gene

Sociodemography and clinical characteristics	Pro268Ser (SNP5)					Gly908Arg (SNP12)
	Mutation (n=17)		No mutation (n=86)		P†	Mutation (n=24)		No mutation (n=79)		P†
	n	(%)	n	(%)		n	(%)	n	(%)
Age at diagnosis*					0.729					0.969
<16 years (A1) (n=34)	5	(29.4)	29	(33.7)		8	(33.3)	26	(32.9)
≥17 years (A2 and A3) (n=69)	12	(70.6)	57	(66.3)		16	(66.7)	53	(67.1)
Location of disease1					0.311					0.033
Ileal (L1) (n=47)	9	(52.9)	38	(44.2)		11	(45.8)	36	(45.6)
Colonic (L2) (n=21)	1	(5.9)	20	(23.3)		1	(4.2)	20	(25.3)
Ileo-colonic (L3) (n=35)	7	(41.2)	28	(32.6)		12	(50.0)	23	(29.1)
Behavior of disease1					0.940					0.295
Non-stricturing, non-penetrating (B1) (n=57)	9	(52.9)	48	(55.8)		10	(41.7)	47	(59.5)
Stricturing (B2) (n=25)	4	(23.5)	21	(24.4)		8	(33.3)	17	(21.5)
Penetrating (B3) (n=21)	4	(23.5)	17	(19.8)		6	(25.0)	15	(19.0)
Perianal disease					0.119					0.984
Yes (n=13)	0	(0.0)	13	(15.1)		3	(12.5)	10	(12.7)
No (n=90)	17	(100)	73	(84.9)		21	(87.5)	69	(87.3)
Family history of CD					0.375					0.102
Yes (n=22)	5	(29.4)	17	(19.8)		8	(33.3)	14	(17.7)
No (n=81)	12	(70.6)	69	(80.2)		16	(66.7)	65	(82.3)
Extraintestinal manifestation					0.491					0.905
Yes (n=18)	4	(23.5)	14	(16.3)		4	(16.7)	14	(17.7)
No (n=85)	13	(76.5)	72	(83.7)		20	(83.3)	65	(82.3)

* According to the Montreal Classification.[18]. † Chi-square tests were used to estimate the P. If the cell count was<5, the Fisher’s exact test was used to estimate the P