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IC50 of compounds for inhibition of P. falciparum growth in vitro
| Antimalaria drug(s) | IC50 in P. falciparum 3D7 | Proposed target | Reference(s) |
|---|---|---|---|
| PPG | 92 ± 16 μM | PfGyr | This study |
| CIP | 3 ± 0.5 μM | PfGyr and off-target effect | 25, 33 |
| Quinolines | 20–100 μM | Gyrase poisoning | 25 |
| ENT1 inhibitors | 5–50 μM | PfENT1 | 34 |
| Acriflavine | 5 mg/kg | DNA replication foci in parasite/indirect decrease in PfGyr activity by interaction with DNA substrate | 35 |
