. 2021 Sep 17;65(10):e01274-21. doi: 10.1128/AAC.01274-21

TABLE 1.

Phenotypic and genotypic profiles of three clinical carbapenem-resistant P. aeruginosa isolates harboring OXA-10-like β-lactamases, evaluated in vivo

Organism	Genotype	MLST^h	MIC (mg/liter)
Organism	Genotype	MLST^h	Ceftazidime	Cefepime	Ceftolozane-tazobactam	Ceftazidime-avibactam	Imipenem	Meropenem
PSA INT-7-65	bla_OXA-56,^abla_OXA-50^b (OXA-904 by BLAST), bla_OXA-392^c, bla_PAO (bla_PDC-117)	260	4^d	32^f	4	4	16	32
PSA INT-9-5	bla_OXA-35,^abla_OXA-488,^bbla_PAO (bla_PDC-35)	235	4^d	32^f	2	2	32	>64
PSA INT-9-11	bla_OXA-10,^abla_OXA-488,^bbla_PAO (bla_PDC-35)	235	8^e	64^g	8	4	16	64

bla_OXA-10-like family. For PSA INT-7-65, bla_OXA-56 could not be distinguished from bla_OXA-101.

bla_OXA-50-like family. For PSA INT-7-65, bla_OXA-50 could not be distinguished from bla_OXA-396 or bla_OXA-494.

bla_OXA-1-like family.

Ceftazidime 2 g q8h 2-h infusion HSR, 100% fT > MIC (9).

Ceftazidime 2 g q8h 2-h infusion HSR, 87% fT > MIC (9).

Cefepime 2 g q8h 2-h infusion HSR, 38% fT > MIC; cefepime 1 g q8h 2-h infusion HSR, 8% fT > MIC (10).

Cefepime 2 g q8h 2-h infusion HSR, 8% fT > MIC; cefepime 1 g q8h 2-h infusion HSR, 0% fT > MIC (10).

MLST, multilocus sequence type.