TABLE 2.
Checkerboard array synergy resultsb
| Drug combination | % Strains against which combination was synergistic (n = 10) | % Strains against which combination was antagonistic (n = 10) | Minimum FICIa (range) | Concn of drugs at individual MICa (range) (μg/ml) | Concn of drugs at minimum FICIa (range) (μg/ml) |
|---|---|---|---|---|---|
| AMB + MIN | 100 | 0 | 0.094–0.5 | 0.5–2 (AMB), >64 (MIN) | 0.031–0.5 (AMB), 8–16 (MIN) |
| CAS + MIN | 100 | 0 | 0.094–0.375 | 0.125–2 (CAS), >64 (MIN) | 0.031–0.125 (CAS), 4–16 (MIN) |
| AMB + RIF | 90 | 0 | 0.188–0.5 | 0.5–2 (AMB), >32 (RIF) | 0.031–0.5 (AMB), 8–16 (RIF) |
| MIN + VOR | 20 | 0 | 0.156–0.188 | >64 (MIN), 0.5–0.5 (VOR) | 4–8 (MIN), 0.063–0.063 (VOR) |
| CAS + VOR | 10 | 0 | 0.313 | 0.25 (CAS), 4 (VOR) | 0.063 (CAS), 0.5 (VOR) |
| MIN + RIF | 0 | 0 | NA | NA | NA |
| AMB + CAS | 0 | 0 | NA | NA | NA |
| AMB + VOR | 0 | 20 | NA | NA | NA |
| CAS + RIF | 0 | 20 | NA | NA | NA |
| RIF + VOR | 0 | 20 | NA | NA | NA |
a
Only includes values from strains against which the combination was synergistic.
b
FIC, fractional inhibitory concentration; FICI, FIC index; AMB, amphotericin B; CAS, caspofungin; VOR, voriconazole; MIN, minocycline; RIF, rifampin.