. 2021 Sep 17;65(10):e00268-21. doi: 10.1128/AAC.00268-21

TABLE 3.

Time-kill results^c

Combination	Synergy				Fungicidal activity
	Combination vs most active single agent (median, range)^a (log₁₀ CFU/ml)		% Strains (n = 5) against which combination was synergistic^b		Combination vs starting inoculum (median, range)^a (log₁₀ CFU/ml)		% Strains (n = 5) against which combination was fungicidal^b
	24 h	48 h	24 h	48 h	24 h	48 h	24 h	48 h
AMB + RIF	−2.40, −4.82–0.0	−1.84, −4.78–0.07	100	60	−2.74, −3.52–1.57	−0.46, −3.21 to −1.91	60	40
AMB + MIN	−2.19, −3.48–0.62	−1.03, −4.99–0.11	100	80	−1.06, −3.30–0.13	0.26, −3.30–2.02	40	40
CAS + MIN	0.51, −0.46–1.07	0.81, −0.34–1.26	0	0	−0.76, 2.46–0.37	−0.91, −2.0–0.44	0	0

Median and range of two concentration combinations for each of 5 strains.

^bAt one or both concentration combinations.

AR Bank, CDC & FDA Antibiotic Resistance Isolate Bank; AMB, amphotericin B; CAS, caspofungin; MIN, minocycline; RIF, rifampin. Synergy was a ≥2-log₁₀ reduction in CFU/ml in the combination compared to the most active agent alone at the specified time point. Fungicidal was a ≥3-log₁₀ CFU/ml reduction compared to starting inoculum at the specified time point.