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. 2021 Sep 17;65(10):e00574-21. doi: 10.1128/AAC.00574-21

TABLE 1.

KPC-producing Klebsiella pneumoniae strains analyzed in this study

Patienta Strain Wardb ST KPC variant KPC amino acid changec Isolation date (mo-day-yr) Sourced CZA treatede MIC (mg/liter)
 WGSf
CZA MEM
P2 2 ICU 512 KPC-67 D272insKDDKDD 01-01-19 BC Yes 48 16 Yes
P4 4 ICU 512 KPC-49 R164S 03-04-19 BC Yes 12 8 Yesg
P5 5 ICU 512 KPC-66 L167delEL 03-11-19 BC Yes 12 8 Yes
P6 6 ICU 512 KPC-29 D272insKDD 04-08-19 BC Yes 24 16 Yesg
P7 7 ICU 512 KPC-3 None 05-02-19 BC No 12 >32 Yesg
P8 8 ICU 512 KPC-67 D272insKDDKDD 05-15-19 BC No 24 16
P9 9 ICU 512 KPC-31 D179Y 06-21-19 BC Yes 32 2 Yes
P10 10 ICU 101 KPC-68 S182insSS 07-20-19 BC Yes 32 2 Yes
P11 11 ICU 512 KPC-67 D272insKDDKDD 07-23-19 BC Yes 16 8
P12 12 MED 101 KPC-3 None 07-26-19 RTS No 8 >16
P13 13 ICU 512 KPC-67 D272insKDDKDD 08-06-19 UR No 32 16
P14 14 MED 307 KPC-31 D179Y 08-07-19 RS No 12 <0.12
P16 16 ICU 101 KPC-39 A172T 09-02-19 BC Yes 24 16 Yesg
P17 17 MED 307 KPC-31 D179Y 10-10-19 BC No 12 <0.12 Yes
P18 18 SU 512 KPC-67 D272insKDDKDD 10-16-19 UR No 24 8
P19 19 SU 101 KPC-66 L167delEL 10-17-19 AF No 12 2 Yesg
P20 20 ICU 512 KPC-67 D272insKDDKDD 10-28-19 BC No 12 8 Yesg
P21 21 MED 101 KPC-31 D179Y 11-15-19 UR No >256 >16 Yesg
P22 22 ICU 101 KPC-31 D179Y 11-29-19 RS No 24 1
P23 23 HEM 307 KPC-31 D179Y 12-03-19 RS No 12 <0.12 Yesg
P24 24 HEM 512 KPC-66 L167delEL 12-09-19 RS No 12 <0.12 Yesg
P26 26 HEM 307 KPC-31 D179Y 12-10-19 RS No 12 <0.12
P27 27 ICU 512 KPC-67 D272insKDDKDD 12-13-19 UR Yes 24 8
P28 28 MED 101 KPC-31 D179Y 12-17-19 AF Yes 24 1
P29 29 ICU 512 KPC-67 D272insKDDKDD 12-30-19 RS No 24 16
P30 30 HEM 307 KPC-31 D179Y 01-13-20 UR No 12 <0.12
P31 31 ICU 101 KPC-68 S182insSS 01-25-20 BC Yes 32 1 Yesg
P20 20-2 ICU 512 KPC-67 D272insKDDKDD 02-10-20 UR No 24 32 Yesg
P32 32 MED 512 KPC-70 D179Y; T268A 02-28-20 RTS Yes >256 2 Yesg
P34 34 MED 111 KPC-69 W165insGL 03-10-20 RS Yes* 8 <0.12 Yesg
P24 24-2 ICU 512 KPC-67 D272insKDDKDD 04-06-20 WS No 16 16 Yesg
P35 35 ICU 101 KPC-31 D179Y 04-17-20 RS Yes* 16 4
P1 1 ICU 512 KPC-3 None 12-03-18 BC No 1 >32 REF
P3 3 ICU 307 KPC-3 None 02-18-19 BC No 0.75 16 REF
P15 15 ICU 512 KPC-3 None 08-17-19 BC No 0.25 >32 REFg
P25 25 HEM 512 KPC-3 None 10-03-19 BC No 1.5 >32 REF
P33 33 HEM 101 KPC-3 None 03-05-20 BC No 2 >32 REF
a

Strains from patients P1, P3, P15, P24, and P32 were CZA-susceptible, carbapenem-resistant strains collected during the surveillance period for genomic comparison. Strains 20-2 and 24-2 were collected from patients P20 and P24, respectively.

b

ICU, intensive care unit; MED, medical clinic; HEM, hematology ward; SU, surgical unit.

c

Amino acid changes detected in comparison with the reference KPC-3 protein (WP_004152396.1). ins, insertion; del, deletion.

d

BC, blood culture; UR, urine; RS, rectal swab; WS, wound swab; RTS, respiratory tract sample; AF, ascitic fluid.

e

CZA treatment prior to CZA-resistant K. pneumoniae strain isolation. An asterisk indicates a patient colonized by a CZA-resistant strain who was previously treated with CZA for bloodstream infection sustained by a CZA-susceptible strain.

f

WGS, whole-genome sequencing; REF, reference strain.

g

Strain analyzed by long-read sequencing (MinIon, Nanopore Oxford Technologies). Strains 21 and 23 were sequenced by MinIon only.