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. 2021 Sep 17;65(10):e00317-21. doi: 10.1128/AAC.00317-21

TABLE 2.

Population pharmacokinetics parameter estimates of the final model and bootstrap analysis

Parametera Final model
 Bootstrap
Estimate % CV 95% CI Median % CV 95% CI
Primary
    tvKa (1/h) 1.38 12.96 1.02–1.73 1.37 12.26 1.09–1.77
    tvV (liters) 103.33 3.00 97.2–109.4 103.27 2.70 97.69–109.17
    tvCL (liters/h) 8.63 2.72 8.17–9.09 8.64 2.57 8.19–9.09
    tvTlag (h) 0.74 6.09 0.65–0.83 0.74 6.25 0.62–0.81
    tvCmultiSD 0.152 12.61 0.11–0.19 0.151 12.46 0.11–0.19
    δVGender1 0.159 23.42 0.08–0.23 0.160 16.53 0.10–0.21
    δVwt 0.415 21.99 0.23–0.59 0.405 19.49 0.21–0.53
    SD, 0 2.91 26.09 1.42–4.40 3.04 26.70 1.78–5.10
Random effect (% IIV)
    ω2Ka 0.47 77.45 0.47 77.45
    ω2V 0.005 7.07 0.005 7.07
    ω2CL 0.034 18.59 0.033 18.31
    ω2Tlag 0.025 15.91 0.03 17.45
a

CV, coefficient of variation; CI, confidence interval; tvKa, typical value of rate of absorption; tvV, typical value of apparent volume of distribution; tvCL, typical value of apparent clearance; tvTlag, typical value of absorption lag time; tvCmultiSD, proportional error on percent scale 0.152 (15.2%); δVGender1, exponent for gender as a covariate for volume of distribution; δVwt, exponent for weight as a covariate for volume of distribution; SD, 0 (square root of CEps variance), additive error on concentration scale (2.91 ng/ml); ω2Ka, variance of interindividual variability for Ka; ω2V, variance of interindividual variability for V; ω2CL, variance of interindividual variability for CL; ω2Tlag, variance of interindividual variability for Tlag.