. 2021 Sep 17;65(10):e00897-21. doi: 10.1128/AAC.00897-21

TABLE 2.

Covariate analysis results

Selection process	Covariate^a	Pharmacokinetic parameter(s)^b	OFV^c	ΔOFV^d	Interindividual variability (%)
Structural model			959.157		55.5
Step 1: Allometric model of wt		CL, V	808.862	150.295^e	27.5
	Age	CL	795.365	13.497^f	22.6
	Sex		808.843	0.019^f	27.5
Step 2: Forward selection (in base of allometric model of wt)	Age	V	809.343	0.481^f
	Sex		808.852	0.01^f
	eGFR	CL	801.794	7.068^f	25.8
	Scr		808.512	0.35^f	27.3
	BUN		806.810	2.052^f	27.3
	CysC		805.736	3.126^f	27.4
Full model	Wt	CL, V	791.732		22.3
	Age	CL
	eGFR	CL
Step 3: Backward selection	eGFR	CL	795.364	3.632^g	22.6
Final model	Wt	CL, V	795.364		22.6
Final model	Age	CL

eGFR, estimated glomerular filtration rate; Scr, serum creatinine concentration; BUN, blood urea nitrogen; CysC, cystatin C.

CL, clearance; V, volume of distribution.

OFV, objective function value.

ΔOFV, variation of objective function value.

ΔOFV of the allometric model of weight and the structural model.

ΔOFV of allometric model in forward selection process and the allometric model of weight.

ΔOFV of allometric model in backward selection process and the full model.