TABLE 3.
Population pharmacokinetic parameters of vancomycin and bootstrap results (n = 1,000)
| Pharmacokinetic parameter | Value | RSEa (%) | Bootstrap median (5% to 95%) |
|---|---|---|---|
| CL (liters/h)b | |||
| θ1 | 2.27 | 5.9 | 2.30 (1.86–2.45) |
| θ2 | 0.11 | 28.7 | 0.11 (0.06–0.34) |
| V (liters)c | |||
| θ3 | 6.82 | 17.2 | 7.15 (6.04–9.35) |
| Interindividual variability (%) | |||
| CL | 22.6 | 14.7 | 22.7 (16.6–30.9) |
| V | 14.7 | 62.7 | 15.6 (5.1–31.7) |
| Residual variability (%) | 31.8 | 7.6 | 31.2 (27.8–34.5) |
a
RSE, relative standard error of the estimate.
b
CL, clearance. CL = θ1 × (wt/15)0.75× (age/4.5)θ2, where wt is body weight, and age is measured in years.
c
V, volume of distribution. V = θ3 × (wt/15).