TABLE 1.

MIC distribution of antibiotics against Mycobacterium fortuitum and MIC₅₀ and MIC₉₀ of M. fortuitum and M. abscessus complex

Antibiotic	Data for Mycobacterium fortuituma																						Data for Mycobacterium abscessus complex
	Total no. of isolates	No. of isolates with MIC (mg/liter) of:																	% S	% I	% R	MIC50	MIC90	MIC50	MIC90
		0.004	0.008	0.015	0.03	0.06	0.12	0.25	0.5	1	2	4	8	16	32	64	128	256
Clarithromycin	86					0	0	0	0	0	0	0	12	18	56b				0.0	0.0	100.0	>16	>16	1	>16
Amikacin	86									59	23	2	2	0	0	0	0b		100.0	0.0	0.0	1	2	16	16
Tobramycin	86									0	0	0	1	59	26b				0.0	0.0	100.0	16	>16	16	>16
Cefoxitin	86											0	0	0	37	39	9	1b	0.0	88.4	11.6	64	128	64	64
Imipenem	86										5	21	43	13	1	3	0b		30.2	65.1	4.7	8	16	16	32
Doxycycline	86						4	8	15	0	0	0	2	0	57b				31.4	0.0	68.6	>16	>16	>16	>16
Linezolid	86									1	8	20	27	16	6	8b			65.1	18.6	16.3	8	32	16	>32
Co-trimoxazole	86							44	15	16	9	0	1	1b					97.7	NA	2.3	0.25	2	8	>8
Ciprofloxacin	86						57	19	8	2	0	0	0b						100.0	0.0	0.0	0.12	0.5	>4	>4
Moxifloxacin	86							67	15	4	0	0	0	0b					100.0	0.0	0.0	0.25	0.5	>8	>8
Delafloxacin	32		0	0	0	1	10	16	5	0	0	0	0	0b					NA	NA	NA	0.25	0.5	>8	>8
Eravacycline	32			24	8	0	0	0	0	0	0	0	0	0	0b				NA	NA	NA			0.12	0.25
Clofazimine	32	0	0	0	0	0	25	7	0	0	0	0	0b						NA	NA	NA	0.12	0.25	0.12	0.25
Bedaquiline	32	5	21	6	0	0	0	0	0	0	0	0	0b						NA	NA	NA	0.008	0.015	0.06	0.12
Rifabutin	32				0	0	0	0	0	0	2	13	16	1	0	0b			NA	NA	NA	8	8	16	32

^aS, susceptible; I, intermediate; R, resistant; NA, not applicable. Blank spaces indicate drug concentrations outside the tested range.

^bIsolates for which there was no inhibition detected, with an MIC was above the tested range.