TABLE 1.
Susceptibility testing of cefiderocol nonsusceptible Acinetobacter baumannii isolates and A. baumannii or E. coli recombinant strains
| Species or strain | Resistance determinant | MIC (μg/ml)a |
||
|---|---|---|---|---|
| FDC (EUMDROXF [CMP1SHIH panel])b | FDC-AVIc | FDC-DPAc | ||
| A. baumannii | OXA-23+PER-7 | >8 (>16) | 0.5 | >16 |
| OXA-23+PER-7 | >8 (>16) | 0.25 | >16 | |
| OXA-23+PER-7 | >8 (>32) | 0.5 | >32 | |
| OXA-23+PER-1 | >8 (16) | 0.5 | 16 | |
| OXA-23+PER-1 | >8 (32) | 0.5 | 32 | |
| OXA-23+PER-1 | >8 (>32) | 0.25 | >32 | |
| OXA-23+PER-7 | >8 (>32) | 0.25 | >32 | |
| OXA-23+PER-7 | >8 (>32) | 2 | >32 | |
| NDM-1 | 2 | ND | ≤0.125 | |
| NDM-1 | 8 | ND | 2 | |
| NDM-1 | 4 | ND | 0.25 | |
| NDM-1 | (>8) 16 | ND | 2 | |
| NDM-1 | 2 | ND | 1 | |
| NDM-1 | 4 | ND | 0.5 | |
| NDM-5 | 8 | ND | 1 | |
| NDM-9 | (>8) 16 | ND | 0.5 | |
| A. baumannii CIP70.10 | PER-1 | 2 | ≤0.03 | ND |
| NDM-1 | 1 | ND | ≤0.125 | |
| NDM-5 | 0.5 | ND | ≤0.125 | |
| NDM-9 | 1 | ND | ≤0.125 | |
| OXA-23 | ≤0.125 | ≤0.125 | ND | |
| OXA-40 | ≤0.125 | ≤0.125 | ND | |
| OXA-48 | ≤0.125 | ≤0.125 | ND | |
| OXA-58 | ≤0.125 | ≤0.125 | ND | |
| CTX-M-2 | ≤0.125 | ≤0.125 | ND | |
| ≤0.125 | ≤0.125 | ND | ||
| E. coli TOP10+PER-1 | PER-1 | 2 (4) | ≤0.03 | ND |
| E. coli TOP10+SHV-2 | SHV-2 | 0.25 | ≤0.03 | ND |
| E. coli TOP10+NDM-1 | NDM-1 | 1 | 1 | ND |
| E. coli TOP10+NDM-5 | NDM-5 | 1 | 1 | ND |
| E. coli TOP10+NDM-9 | NDM-9 | 2 | 2 | ND |
| E. coli TOP10+OXA-23 | OXA-23 | 0.03 | ≤0.03 | ND |
| E. coli TOP10+OXA-40 | OXA-40 | 0.03 | ≤0.03 | ND |
| E. coli TOP10+OXA-48 | OXA-48 | 0.03 | ≤0.03 | ND |
| E. coli TOP10+OXA-58 | OXA-58 | 0.03 | ≤0.03 | ND |
| E. coli TOP10+BEL-2 | BEL-2 | 0.5 | ≤0.03 | ND |
| E. coli TOP10 | 0.03 | ≤0.03 | ND | |
a
FDC, cefiderocol; AVI, avibactam at 4 μg/ml; DPA, dipicolinic acid at 100 μg/ml; ND, not determined.
b
Commercial cefiderocol MIC panels used in this study. If both MICs were the same value, then only one value is indicated.